{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:02:22Z","timestamp":1785240142749,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Foslevodopa\/foscarbidopa continuous subcutaneous infusion (LDp\/CDp CSI) has emerged as an effective and well\u2010tolerated therapy for reducing OFF and increasing non\u2010troublesome ON in advanced Parkinson's disease (PD). Neuropsychiatric adverse events (AEs) have been reported in both clinical trials and real\u2010world studies, with some\n                      <jats:italic>real\u2010world<\/jats:italic>\n                      cohorts suggesting higher rates among patients with prior hallucinations or cognitive impairment. The present study aimed to determine the incidence and risk factors of neuropsychiatric AEs in a large prospective\n                      <jats:italic>real\u2010world<\/jats:italic>\n                      cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from the DATs\u2010PD GETM Spanish Registry, an observational, prospective, multicenter, open\u2010label study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>214 patients treated with LDp\/CDp CSI were included. Median age was 69\u2009years, and median disease duration was 12\u2009years. At baseline, 35% had cognitive impairment, 25.7% hallucinations\/psychosis, and 26.2% impulse control disorders (ICDs). During follow\u2010up after initiation (median 163\u2009days), 19.2% developed at least one neuropsychiatric AE, mostly mild\u2013moderate, and only 2.3% required device removal. Most events occurred more than 1\u2009month after treatment initiation. In adjusted Cox, none of the evaluated variables were associated with the development of hallucinations\/psychosis\/confusion. The presence of ICD at baseline was associated with an increased risk of ICD\u2010related AEs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Neuropsychiatric AEs, mainly hallucinations\/psychosis, occurred in a clinically relevant proportion of patients treated with LDp\/CDp CSI. However, they were generally mild\u2010to\u2010moderate and rarely led to treatment discontinuation. Except for ICD, baseline cognitive and psychotic features were not associated with higher incidence. These findings support its use in appropriately selected patients while highlighting the importance of individualized careful clinical monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70693","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T12:10:58Z","timestamp":1783339858000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neuropsychiatric Adverse Events Associated With Foslevodopa\/Foscarbidopa Continuous Subcutaneous Infusion in Clinical Practice: A Multicenter Study"],"prefix":"10.1111","volume":"33","author":[{"given":"David","family":"Campo\u2010Caballero","sequence":"first","affiliation":[{"name":"Department of Neurology, Movement Disorders Unit Hospital Universitario Donostia  San Sebasti\u00e1n Spain"},{"name":"Department of Neurosciences Biogipuzkoa Health Research Institute  San Sebasti\u00e1n Spain"},{"name":"Neurosciences University of the Basque Country (UPV\/EHU)  San Sebasti\u00e1n Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2010Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9316-1772","authenticated-orcid":false,"given":"Jon","family":"Rodriguez\u2010Antiguedad","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2010Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"},{"name":"Medicine Department Universitat Aut\u00f2noma de Barcelona (UAB)  Barcelona Spain"},{"name":"Movement Disorders Unit, Neurology Department Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Institut D'investigacions Biom\u00e8diques\u2010Sant Pau (IIB\u2010Sant Pau)  Barcelona 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