{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:36:00Z","timestamp":1787315760477,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["848044001"],"award-info":[{"award-number":["848044001"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>B\u2010cell repopulation patterns in ocrelizumab treated patients with multiple sclerosis are highly variable between individuals, but the course of B\u2010cell reoccurrence after subsequent doses within an individual is not yet determined. Our aim was to determine the intraindividual variability of CD19+ B\u2010cell repopulation after each ocrelizumab dose when using CD19+ B\u2010cell guided interval dosing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a prospective cohort study, as part of the ongoing BLOOMS trial, investigating participants randomised for B\u2010cell guided interval dosing of ocrelizumab with \u2265\u20092 dosing intervals. Coefficients of variation were calculated for time from last ocrelizumab dose to first CD19+ B\u2010cell measurement \u2265\u20090.01\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      cells\/L.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010five participants with a total of 209 B\u2010cell guided intervals were included. Time from last dose to first appearance of CD19+ B\u2010cell count \u2265\u20090.01\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      cells\/L showed wide variability between individuals (20.6\u201372.1\u2009weeks), but the median variation was 5.6% (IQR: 3.1\u20138.4) within an individual. This translated to a variation of 2\u2009weeks per dosing interval on average.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Time to CD19+ B\u2010cell repopulation after each ocrelizumab dose is individually stable. This finding could pave the way for easier and more accessible future personalised interval dosing of B\u2010cell depleting therapies if this stability is confirmed in long\u2010term treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70695","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:32:51Z","timestamp":1783431171000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Individual Variability of\n                    <scp>CD19<\/scp>\n                    + B\u2010Cell Repopulation in People With Multiple Sclerosis Treated With Extended Interval Dosing of Ocrelizumab"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1230-1366","authenticated-orcid":false,"given":"Laura","family":"Hogenboom","sequence":"first","affiliation":[{"name":"MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience Amsterdam UMC Location VUmc  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa G.","family":"Schoof","sequence":"additional","affiliation":[{"name":"MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience Amsterdam UMC Location VUmc  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liza M. Y.","family":"Gelissen","sequence":"additional","affiliation":[{"name":"MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience Amsterdam UMC Location VUmc  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jop","family":"Mostert","sequence":"additional","affiliation":[{"name":"Department of Neurology Rijnstate Ziekenhuis  Arnhem the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luuk","family":"van Rooij","sequence":"additional","affiliation":[{"name":"Department of Neurology Maasstad Ziekenhuis  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elske","family":"Hoitsma","sequence":"additional","affiliation":[{"name":"Department of Neurology Alrijne Ziekenhuis  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caspar E. P.","family":"van Munster","sequence":"additional","affiliation":[{"name":"Department of Neurology Amphia Ziekenhuis  Breda the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"van Eijk","sequence":"additional","affiliation":[{"name":"Department of Neurology Jeroen Bosch Ziekenhuis  's Hertogenbosch the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nienke F.","family":"Kalkers","sequence":"additional","affiliation":[{"name":"Department of Neurology OLVG  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten S.","family":"Adriani","sequence":"additional","affiliation":[{"name":"Department of Neurology OLVG  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Vennegoor","sequence":"additional","affiliation":[{"name":"Department of Neurology Flevoziekenhuis  Almere the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse M. 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