{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:02:34Z","timestamp":1785240154498,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R310\u20102018\u20103711"],"award-info":[{"award-number":["R310\u20102018\u20103711"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R403\u20102022\u20101352"],"award-info":[{"award-number":["R403\u20102022\u20101352"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","award":["DNRF188"],"award-info":[{"award-number":["DNRF188"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Experimental studies show inflammatory cytokines can modulate calcitonin gene\u2010related peptide (CGRP) signaling, suggesting systemic inflammatory markers might reflect biological processes relevant to anti\u2010CGRP therapies. We aimed to determine whether serum high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP) and tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) are associated with erenumab response in adults with migraine and assess longitudinal biomarker changes during and after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective, observational single\u2010center study, adults with episodic or chronic migraine self\u2010administered 140\u2009mg erenumab subcutaneously every 4\u2009weeks for 24\u2009weeks. Serum was collected at baseline, Week 24 (end of treatment), and Week 48 (24\u2009weeks post\u2010treatment). Treatment response was defined as a \u2265\u200950% reduction in monthly migraine days from baseline to Weeks 13\u201324. Logistic and linear regression models evaluated associations between baseline biomarkers and response, while longitudinal changes were analyzed using linear mixed\u2010effects models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 679 enrolled participants, serum was analyzed in 623. Among 541 with sufficient data to determine response, 281 (51.9%) were responders. Neither baseline hs\u2010CRP (OR 1.04; 95% CI 0.96\u20131.12;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.30) nor TNF\u2010\u03b1 (OR 0.75; 95% CI 0.49\u20131.16;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.20) predicted treatment response. TNF\u2010\u03b1 increased from baseline to Week 24 (mean rise 3.0%; 95% CI 0.5%\u20135.4%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030), but no responder\u2013non\u2010responder differences were found.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Peripheral inflammatory biomarkers such as hs\u2010CRP and TNF\u2010\u03b1 neither predict response nor change meaningfully during CGRP\u2010receptor blockade. These results suggest broadly applied inflammatory markers do not capture treatment\u2010relevant biology and highlight the need for mechanism\u2010specific biomarkers to advance personalized migraine therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70714","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T07:16:18Z","timestamp":1784877378000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Serum hs\u2010\n                    <scp>CRP<\/scp>\n                    and\n                    <scp>TNF<\/scp>\n                    \u2010\u03b1 With Therapeutic Response to Erenumab for Migraine Prevention: A Registry for Migraine (\n                    <scp>REFORM<\/scp>\n                    ) Study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0339-1417","authenticated-orcid":false,"given":"William K.","family":"Karlsson","sequence":"first","affiliation":[{"name":"Department of Neurology, Center for Discoveries in Migraine and Danish Headache Center Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3384-3579","authenticated-orcid":false,"given":"Rune H.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Discoveries in Migraine and Danish Headache Center Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Translational Research Center Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7015-3369","authenticated-orcid":false,"given":"Haidar M.","family":"Al\u2010Khazali","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Discoveries in Migraine and Danish Headache Center Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Translational Research Center Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2589-738X","authenticated-orcid":false,"given":"Dorte A.","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research University of Southern Denmark  Odense Denmark"},{"name":"Department of Biochemistry and Immunology University Hospital of Southern Denmark \u2013 Lillebaelt Hospital  Vejle Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6668-4714","authenticated-orcid":false,"given":"Jonna S.","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research University of Southern Denmark  Odense Denmark"},{"name":"Department of Biochemistry and Immunology University Hospital of Southern Denmark \u2013 Lillebaelt Hospital  Vejle Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0951-5804","authenticated-orcid":false,"given":"Messoud","family":"Ashina","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Discoveries in Migraine and Danish Headache Center Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen 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