{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:22:28Z","timestamp":1787728948025,"version":"build-2784847793"},"reference-count":198,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The neurovascular unit (NVU) is a core structural and functional entity involved in migraine pathogenesis. Acupuncture may exert therapeutic effects by protecting NVU integrity. This narrative review aims to summarize the current evidence on the mechanisms by which acupuncture protects the NVU in migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed and synthesized relevant literature focusing on the effects of acupuncture on neuronal excitation, blood\u2013brain barrier (BBB) components, neuroinflammation, and energy metabolism in the context of migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Acupuncture protects the NVU through four major pathways: (1) Acupuncture inhibits pathological excitation of neurons, including activating the endogenous pain regulation system, regulating the balance of neurotransmitters and receptors, and inhibiting peripheral sensitization and inflammation; (2) Acupuncture maintains the integrity of the BBB, specifically involving improving endothelial cell function and tight junctions (TJs), regulating astrocyte reactivity, enhancing pericyte function, and inhibiting extracellular matrix (ECM) degradation; (3) Acupuncture regulates neuroinflammation mediated by microglia; (4) Acupuncture improves energy metabolism and oxidative stress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Acupuncture exerts multi\u2010target, comprehensive protective effects on NVU damage in migraine. These findings provide a mechanistic basis for its clinical application and may offer new therapeutic directions for migraine management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70730","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:01:32Z","timestamp":1787551292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanisms of Acupuncture on the Neurovascular Unit in Migraine: A Narrative Review"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3854-4940","authenticated-orcid":false,"given":"Yajie","family":"Wang","sequence":"first","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linbo","family":"Shen","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8474-7121","authenticated-orcid":false,"given":"Linjing","family":"Song","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8849-5611","authenticated-orcid":false,"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningle","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayong","family":"Ma","sequence":"additional","affiliation":[{"name":"Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xiong","sequence":"additional","affiliation":[{"name":"Shenzhen Hospital of Beijing University of Chinese Medicine (Longgang)  Shen Zhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,23]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00328-4"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-020-01208-0"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx223"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.3344\/kjp.2022.35.1.4"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.1640"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119127"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14767"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2026.1827022"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/03331024261434209"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14080966"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jebm.70059"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-023-0989-7"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11050813"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2024.106772"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-022-00703-z"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-03998-9"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-025-02130-z"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/03331024231164322"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-025-02107-y"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01303.x"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-025-02044-w"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00059.2021"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2020.1724285"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(00)00187-8"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106720"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-3787(05)85108-2"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom15060892"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.121120"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/408136"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10020434"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-024-01807-1"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.01.027"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-025-03503-6"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-017-0992-8"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-022-01394-z"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-024-01894-0"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-025-01998-1"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP283362"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25169071"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-025-02080-6"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.1.199"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-008-9758-x"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-024-01893-1"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.10.062"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30185-1"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202300134"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.03.003"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010161"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-025-02151-8"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24097897"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S226922"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-1722-y"},{"key":"e_1_2_15_55_1","first-page":"118","article-title":"Acupuncture Relieves Pain by Inhibiting Expression of Cx43 in Astrocytes and Release of Interfe\u2010Ron\u2010\u03b3 in Neurons of Trigeminal Spinal Nucleus in Rats With Migraine","volume":"48","author":"Liu Y.","year":"2023","journal-title":"Zhen Ci Yan Jiu = Acupuncture Research"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106668"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108131"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1130-9"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2023.01.002"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.71877"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1116-7"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2023.10.025"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e32834a1079"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims-24-916"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1177\/03331024221144783"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06425"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X21994395"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101994"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010919-023755"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2646-08.2008"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102066"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2021.05.005"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1177\/17448069231202882"},{"key":"e_1_2_15_74_1","first-page":"1029","article-title":"Effect of Acupuncture Serum on Expression of Microtubule Associated Protein\u20102 and Nerve Growth Associated Protein\u201043 in Mg2+\u2212Free\u2010Cultured Hippocampal Neurons of Neonatal Rats","volume":"46","author":"Zhang H.","year":"2021","journal-title":"Zhen Ci Yan Jiu = Acupuncture Research"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.757628"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1177\/1744806921997654"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2017-011410"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00045.2019"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2020.1815191"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2024.102912"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2015"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-050224-111631"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad191"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S504892"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2026.138505"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13030260"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114193"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2019.11.009"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-020-00230-3"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.57.2.4"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-014-2096-1"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2022.147937"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14081665"},{"key":"e_1_2_15_94_1","first-page":"2559","article-title":"Impact of Migraine Attacks on the Blood\u2010Brain Barrier","volume":"123","author":"Gao H.\u2010M.","year":"2010","journal-title":"Chinese Medical Journal"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200421227"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.1022455"},{"key":"e_1_2_15_97_1","first-page":"E633","article-title":"Recurrent Headache Increases Blood\u2010Brain Barrier Permeability and VEGF Expression in Rats","volume":"21","author":"Mi X.","year":"2018","journal-title":"Pain Physician"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2014-010612"},{"key":"e_1_2_15_99_1","first-page":"1079","article-title":"Effect of ZHU Lian's Type II Inhibition Acupuncture on Chronic Migraine and Serum 5\u2010HT, VEGF, CGRP","volume":"41","author":"Ke H.\u2010K.","year":"2021","journal-title":"Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.3727\/036012914X14109544776178"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-020-01111-8"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2025.102952"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-021-03338-6"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2022.102584"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1824"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci15030279"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-021-01382-9"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-025-01202-1"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20911331"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/642081"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041156"},{"key":"e_1_2_15_112_1","first-page":"633","article-title":"Pericyte Morphology and Function","volume":"36","author":"Alarcon\u2010Martinez L.","year":"2021","journal-title":"Histology and Histopathology"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25126592"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmr.2025.100052"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.153.3.543"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.07.001"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.2174\/0115672026361204241115112340"},{"key":"e_1_2_15_118_1","first-page":"1079","article-title":"Effects of Electroacupuncture on the Microvascular Structure and Related Protein Expression in the Hippocampus of Vascular Dementia Rats","volume":"48","author":"Du K.\u2010R.","year":"2023","journal-title":"Zhen Ci Yan Jiu = Acupuncture Research"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-024-01250-2"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1893-0"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03205.x"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031413"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2009.07.009"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70016-X"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.143902"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20040811"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.09.103"},{"key":"e_1_2_15_128_1","first-page":"286","article-title":"Effect of a Novel, Orally Active Matrix Metalloproteinase\u20102 and \u20109 Inhibitor in Spinal and Trigeminal Rat Models of Neuropathic Pain","volume":"29","author":"Henry M. A.","year":"2015","journal-title":"Journal of Oral & Facial Pain and Headache"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-025-01370-7"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.997786"},{"key":"e_1_2_15_131_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20951995"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-9070-5"},{"key":"e_1_2_15_133_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00176"},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-017-2881-1"},{"key":"e_1_2_15_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2025.120078"},{"key":"e_1_2_15_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2024.103957"},{"key":"e_1_2_15_137_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417703764"},{"key":"e_1_2_15_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1472"},{"key":"e_1_2_15_139_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8039"},{"key":"e_1_2_15_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0216-y"},{"key":"e_1_2_15_141_1","first-page":"1064","article-title":"Electroacupuncture of Specific Acupoints of Shaoyang Meridian Relieves Progression of Chronic Migrain by Down\u2010Regulating Expression of P2Y12 Receptor in Rats","volume":"50","author":"Qiu Y.","year":"2025","journal-title":"Zhen Ci Yan Jiu"},{"key":"e_1_2_15_142_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.7.4320"},{"key":"e_1_2_15_143_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13040541"},{"key":"e_1_2_15_144_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12081100"},{"key":"e_1_2_15_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110764"},{"key":"e_1_2_15_146_1","doi-asserted-by":"publisher","DOI":"10.1177\/17448069241258113"},{"key":"e_1_2_15_147_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-024-01739-w"},{"key":"e_1_2_15_148_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-025-05449-5"},{"key":"e_1_2_15_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.70177"},{"key":"e_1_2_15_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.07.030"},{"key":"e_1_2_15_151_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200110000-00001"},{"key":"e_1_2_15_152_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-025-00699-w"},{"key":"e_1_2_15_153_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666180622154411"},{"key":"e_1_2_15_154_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-024-01872-6"},{"key":"e_1_2_15_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.01.002"},{"key":"e_1_2_15_156_1","doi-asserted-by":"publisher","DOI":"10.1177\/10738584221090836"},{"key":"e_1_2_15_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2025.01.015"},{"key":"e_1_2_15_158_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13101172"},{"key":"e_1_2_15_159_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph12020054"},{"key":"e_1_2_15_160_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-021-03335-9"},{"key":"e_1_2_15_161_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.1013328"},{"key":"e_1_2_15_162_1","doi-asserted-by":"publisher","DOI":"10.4103\/bc.bc_95_23"},{"key":"e_1_2_15_163_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934965"},{"key":"e_1_2_15_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2562"},{"key":"e_1_2_15_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep20298"},{"key":"e_1_2_15_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2012.10.016"},{"key":"e_1_2_15_167_1","first-page":"17","article-title":"Effect of Electroacupuncture on Cortical Spreading Depression and Plasma CGRP and Substance P Contents in Migraine Rats","volume":"35","author":"Shi H.","year":"2010","journal-title":"Zhen Ci Yan Jiu = Acupuncture Research"},{"key":"e_1_2_15_168_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-026-01338-8"},{"key":"e_1_2_15_169_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S225431"},{"key":"e_1_2_15_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114516"},{"key":"e_1_2_15_171_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-022-00844-7"},{"key":"e_1_2_15_172_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-024-02276-6"},{"key":"e_1_2_15_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(02)00006-1"},{"key":"e_1_2_15_174_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2010.16.3.230"},{"key":"e_1_2_15_175_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3672"},{"key":"e_1_2_15_176_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1151892"},{"key":"e_1_2_15_177_1","article-title":"Acupuncture for the Prevention of Episodic Migraine","volume":"2016","author":"Linde K.","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_15_178_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01424.x"},{"key":"e_1_2_15_179_1","article-title":"Acupuncture for Migraine Prophylaxis","volume":"540","author":"Linde K.","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_15_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2020.08.005"},{"key":"e_1_2_15_181_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-025-02240-8"},{"key":"e_1_2_15_182_1","doi-asserted-by":"publisher","DOI":"10.1177\/03331024221145916"},{"key":"e_1_2_15_183_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m697"},{"key":"e_1_2_15_184_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.9378"},{"key":"e_1_2_15_185_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200670"},{"key":"e_1_2_15_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2020.10.008"},{"key":"e_1_2_15_187_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e318030c904"},{"key":"e_1_2_15_188_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00598.x"},{"key":"e_1_2_15_189_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411420585"},{"key":"e_1_2_15_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70382-9"},{"key":"e_1_2_15_191_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-007-0416-5"},{"key":"e_1_2_15_192_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38512.405440.8F"},{"key":"e_1_2_15_193_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2004.04077.x"},{"key":"e_1_2_15_194_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-011-0525-4"},{"key":"e_1_2_15_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2022.103168"},{"key":"e_1_2_15_196_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01640.x"},{"key":"e_1_2_15_197_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102421989620"},{"key":"e_1_2_15_198_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2012.01376.x"},{"key":"e_1_2_15_199_1","doi-asserted-by":"publisher","DOI":"10.1136\/aim.24.1.13"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70730","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.70730","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:30:55Z","timestamp":1787725855000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.70730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":198,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/ene.70730"],"URL":"https:\/\/doi.org\/10.1111\/ene.70730","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2025-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70730"}}