{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:23:11Z","timestamp":1787728991677,"version":"build-2784847793"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100019032","name":"Regionala Forskningsr\u00e5det Uppsala\/\u00d6rebro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023670","name":"Nyckelfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023670","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Brain\u2010derived tau (BD\u2010tau) is a predominantly CNS\u2010derived form of tau protein detectable in blood that reflects brain injury and has emerged as a potential biomarker in ischemic stroke for assessing neuronal damage, monitoring infarct progression, and predicting functional outcome. However, its temporal profile and the optimal timing for correlation with infarct volume remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cohort study included patients with ischemic stroke, with venous blood samples collected daily during the first week and at 3\u2009months after symptom onset. Infarct volume was assessed by MRI at 48\u201372\u2009h. Plasma BD\u2010tau concentrations were measured using a Simoa assay. Linear mixed\u2010effects models were used to analyze changes in biomarker levels. The optimal time point for correlation between BD\u2010tau and infarct volume was identified using a 24\u2010h moving\u2010window Pearson correlation analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010four patients (median age 78\u2009years, 50% female) contributed 285 plasma samples. Plasma levels of BD\u2010tau followed a parabolic trajectory reaching a peak approximately 5\u2009days after symptom onset. After 90\u2009days, the concentration of BD\u2010tau was lower than in the last measurement of the first week. The strongest correlation between BD\u2010tau and infarct volume occurred at 105\u2009h (4.4\u2009days) (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.89, 95% CI: 0.78\u20130.95) after symptom onset.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Plasma BD\u2010tau exhibits a distinct temporal profile after ischemic stroke, with peak levels and maximal correlation with infarct volume occurring around Day 4\u20135. These findings have important implications for interpreting BD\u2010tau levels and optimizing sampling strategies in clinical studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link>\n                      NCT03812666\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70735","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T12:47:53Z","timestamp":1787143673000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasma Profile of Brain\u2010Derived Tau After Ischemic 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