{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:46:51Z","timestamp":1791985611285,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Migraine's economic burden is mostly due to reduced work productivity, which is underestimated by commonly used patient\u2010reported outcome measures (PROMs). In this prospective, multicentric, real\u2010world study, we used the HEADWORK questionnaire (HWq), a disease\u2010specific work\u2010related PROM, to assess the impact of anti\u2010calcitonin gene receptor peptide (anti\u2010CGRP) monoclonal antibodies (mAbs) on work\u2010related limitations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Migraine patients eligible for treatment with anti\u2010CGRP mAbs were enrolled from three headache centers: IRCCS C.Besta, Mondino Foundation and Policlinico Campus Bio\u2010Medico. Migraine days per month (MMDs), monthly acute medications (MAMs), and HWq were collected every 3\u2009months up to 12\u2009months of follow\u2010up. A GLM design was used to address change in HWq scales' score (primary endpoint), MAMs and MMDs; we also tested whether change in HWq differed across responders' group and defined minimum clinically important difference (MCID) for HWq.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 175 patients (130 females, mean age 48.9\u2009\u00b1\u20098.8) 152 completed the study. Among them: 37 (24.3%) were non\u2010responders, 69 (45.4%) were responders, and 46 (30.3%) were super\u2010responders. A reduction in all endpoints was observed since the first 3\u2009months of treatment and maintained up to 12\u2010month follow\u2010up. Time*group interaction showed a superior effect, both in HWq scales and MAMs, with super\u2010responders achieving the best outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A significant reduction in MMDs and MAMs and an improvement in both HWq scales in patients under mAbs treatment was found from the 3\u2010month follow\u2010up onwards. The positive impact on work\u2010related disability should be taken into consideration in planning cost\u2010effectiveness evaluations and drug policy strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70738","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:39:57Z","timestamp":1788158397000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Migraine and Work\u2010Disability: New Treatments Reduce Work\u2010Related Burden Among Migraine Population"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4834-2045","authenticated-orcid":false,"given":"Danilo Antonio","family":"Montisano","sequence":"first","affiliation":[{"name":"Headache Center Fondazione IRCCS Istituto Neurologico Carlo Besta  Milano 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