{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:46:48Z","timestamp":1791985608662,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201020\u20101\u20100775"],"award-info":[{"award-number":["W81XWH\u201020\u20101\u20100775"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1084240"],"award-info":[{"award-number":["1084240"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009287","name":"NSW Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009287","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012066","name":"Wings for Life","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001061","name":"Rebecca L. Cooper Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Spinal cord injury (SCI) results in neurodegeneration both at and above the lesion site. While cervical cord atrophy is well characterised in populations of mixed cervical, thoracic and\/or lumbar injuries, the remote morphological changes in cervical cord following thoracic SCI remain unclear. The present study aimed to quantify cervical spinal cord morphology at C2\u2013C3 in individuals with complete thoracic SCI and compare these metrics to matched controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were 52 adults with complete thoracic SCI and 55 neurologically healthy, able\u2010bodied controls matched for age and sex. Extracted cervical metrics included mean cross\u2010sectional area (CSA), antero\u2010posterior (AP) and right\u2013left (RL) diameters, eccentricity, solidity, orientation and cord length. Group differences were assessed using linear mixed models adjusted for age, sex and scanning sites. Impacts of experiencing SCI\u2010related chronic neuropathic pain on these metrics were explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to controls, the thoracic SCI group showed significantly reduced cervical CSA and AP\/RL diameters, consistent with remote atrophy, and increased eccentricity, indicating a more flattened cord profile. Solidity, orientation and cord length showed no group differences, supporting metric reliability and absence of segmentation artefacts. Although no difference was evident among the SCI groups, those experiencing chronic neuropathic pain had larger eccentricity than controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Complete thoracic SCI is associated with significant remote cervical cord degeneration, even in the absence of direct cervical injury. Results highlight that neurodegenerative processes propagate along ascending and descending spinal pathways. Cervical morphometry metrics, particularly CSA and eccentricity, may represent biomarkers of distal neurodegeneration following thoracic SCI and inform future therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70750","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:36:24Z","timestamp":1789043784000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cervical Atrophy Following Complete Thoracic Spinal Cord Injury: Insights From a Multinational Cohort"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8569-7139","authenticated-orcid":false,"given":"Yann","family":"Quid\u00e9","sequence":"first","affiliation":[{"name":"NeuroRecovery Research Hub, School of Psychology The University of New South Wales (UNSW) Sydney  Sydney New South Wales Australia"},{"name":"Centre for Pain IMPACT Neuroscience Research 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