{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:46:50Z","timestamp":1791985610826,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate whether selective radiofrequency thermocoagulation (RFTC) targeting mesiotemporal structures, while sparing the piriform cortex (PC), can achieve seizure freedom in drug\u2010resistant mesial temporal lobe epilepsy (MTLE), and to assess whether said seizure freedom is associated with an indirect disconnection of the PC within the epileptogenic network.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was performed on 32 patients (mean age 27.81\u2009\u00b1\u200913.37\u2009years) with drug\u2010resistant MTLE who underwent stereoelectroencephalography (SEEG)\u2010guided RFTC. Volumetric and structural connectivity (SC) analyses were conducted using pre\u2010 and postoperative T1\u2010weighted (T1W) and diffusion\u2010weighted imaging (DWI). The regions of interest (ROIs) targeted included the hippocampus, amygdala, rhinal cortex, and parahippocampal cortex, while the PC was spared. Network metrics assessed pre\u2010 and postoperative SC changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At a mean follow\u2010up of 40.63\u2009\u00b1\u200916.36\u2009months, 25 patients (78.1%) became seizure free (SF). SF patients had significantly greater ablation volumes in the amygdala (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026) and rhinal cortex (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023) compared to non\u2010seizure\u2010free (NSF) patients. SF patients showed significant postoperative reductions in SC across all mesiotemporal ROIs, including the spared PC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.020). NSF patients exhibited no significant SC changes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Seizure freedom following SEEG\u2010guided RFTC is associated with widespread disruption of SC in mesiotemporal networks, including the spared PC. These findings support the hypothesis that seizure freedom following the ablation of key mesiotemporal ROIs can induce an indirect disconnection of the PC through its connected nodes, offering a safer therapeutic option for MTLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70751","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:08:05Z","timestamp":1789189685000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Seizure Freedom Despite Piriform Cortex Sparing: Structural Connectivity Remodeling After\n                    <scp>SEEG<\/scp>\n                    \u2010Guided Mesial Temporal\n                    <scp>RFTC<\/scp>"],"prefix":"10.1111","volume":"33","author":[{"given":"St\u00e9phane","family":"Jean","sequence":"first","affiliation":[{"name":"Pediatric Epilepsy Center Fuzhou First General Hospital Affiliated with Fujian Medical University  Fuzhou 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