{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:59:00Z","timestamp":1791547140515,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Co\u2010occurrence of facioscapulohumeral muscular dystrophy (FSHD) and myasthenia gravis (MG) is rare but clinically critical, as treatable MG symptoms may be misattributed to FSHD progression. This systematic review and meta\u2010analysis aimed to comprehensively characterize patients with both conditions and to quantitatively synthesize the available individual patient data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following PRISMA 2020 guidelines, we searched four databases until 3 April 2026 for original reports providing individual\u2010patient data on confirmed FSHD and MG co\u2010occurrence. We performed descriptive and quantitative syntheses of clinical, genetic, and therapeutic variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine studies were systematically reviewed, with 29 patients contributing to on. FSHD onset significantly preceded MG onset, with a pooled mean interval of 24.21\u2009years. The pooled mean age at MG onset was 62.62\u2009years. All tested patients were acetylcholine receptor antibody positive. MG frequently presented with ocular and bulbar manifestations. Crucially, the pooled estimate for clinical improvement following standard MG\u2010directed therapies was 89.7%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MG in FSHD patients typically emerges late in adulthood as an antibody\u2010positive autoimmune synaptopathy. Recognizing new ocular or bulbar weakness as superimposed MG is essential, providing a highly treatable avenue to reverse functional decline in patients with established myopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70752","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:48:29Z","timestamp":1791546509000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Co\u2010Occurrence of Facioscapulohumeral Muscular Dystrophy and Myasthenia Gravis: A Systematic Review and Meta\u2010Analysis of Individual Patient Data"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5620-3267","authenticated-orcid":false,"given":"Pricilla Yani","family":"Gunawan","sequence":"first","affiliation":[{"name":"Department of Neurology Faculty of Medicine, Universitas Pelita Harapan  Tangerang Banten Indonesia"},{"name":"Department of Neurology Siloam Hospital Lippo Village  Tangerang Banten Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8771-2163","authenticated-orcid":false,"given":"Jeremiah Hilkiah","family":"Wijaya","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.70477"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010021\u201003185\u20107"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000539577"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.86566"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10112235"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4081\/ni.2019.8191"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.17161\/rrnmf.v6i1.22973"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102025\u2010337550"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"issue":"1","key":"e_1_2_10_11_1","first-page":"28","article-title":"A Rare Case of Facioscapulohumeral Muscular Dystrophy and Myasthenia Gravis","volume":"11","author":"Asadollahi M.","year":"2012","journal-title":"Iran Journal of Neurology"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010018\u20103554\u20104"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/pl00007868"},{"issue":"4","key":"e_1_2_10_14_1","first-page":"179","article-title":"A Patient With Facioscapulohumeral Muscular Dystrophy Accompanied by Myasthenia Gravis","volume":"41","author":"Sakuma H.","year":"2001","journal-title":"Rinsh\u014d Shinkeigaku"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20118"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2014.13916"},{"key":"e_1_2_10_17_1","volume-title":"GeneReviews","author":"Preston M. 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