{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:58:42Z","timestamp":1790413122169,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100011096","name":"Jazz Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We report a single centre experience of cannabidiol use as adjunctive treatment in adults with Lennox\u2013Gastaut Syndrome (LGS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective review of adults with LGS treated with cannabidiol with clinical data collected from electronic records and caregiver standardised seizure diaries with seizure\u2010related outcomes assessed at baseline, 6\u2009months, and last follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010nine adults (median age 29\u2009years; 40 male) were included. Median follow\u2010up was 41\u2009months. Four patients died unrelated to cannabidiol treatment. Sixty\u2010seven (86%) remained on treatment at last follow\u2010up. Across all seizure types, 59.5% achieved \u2265\u200950% reduction at 6\u2009months and 67.1% at last follow\u2010up. Among those with \u2018Drop Seizures\u2019 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200978), 50% achieved &gt;\u200950% reduction at 6\u2009months and 61.5% at last follow\u2010up. \u2018Drop Seizure\u2019 responder rates were numerically higher with clobazam &gt;\u20095\u2009mg\/day, but with no statistically significant dose\u2013response relationship seen. Seizure\u2010free days increased (baseline 5.7\/month; last follow\u2010up 12.5\/month). Seizure\u2010related hospital admissions and injuries declined. Cognitive or behavioural improvements were reported in 48 patients (60.8%); there was no statistically significant association with achieving \u2265\u200950% seizure reduction. Drowsiness (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200933) was the most frequent adverse event often related to drug\u2013drug interactions. Diarrhoea (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924) was more common than previously reported. Side\u2010effects necessitated ASM adjustments in 51 patients. Fourteen were able to withdraw one or more ASMs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CBD was associated with sustained effectiveness and good tolerability in adults with LGS, with high retention and improvement in seizure and other clinically meaningful outcomes. Adverse effects, mainly interaction\u2010related, were usually managed with concomitant medication adjustments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70760","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:11:32Z","timestamp":1790410292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cannabidiol in Adults With Lennox\u2013Gastaut Syndrome: Real\u2010World Experience"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7074-8047","authenticated-orcid":false,"given":"Pyae","family":"Aung","sequence":"first","affiliation":[{"name":"Department of Neurology King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Neurology King's College Hospital  London 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