{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:50:04Z","timestamp":1791985804275,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["Current Research 2026"],"award-info":[{"award-number":["Current Research 2026"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary headaches, particularly migraine, are prevalent disorders insufficiently characterized in older adults. This multicentre study evaluated headache diagnoses, focusing on migraine, across age groups in headache centers participating in the Italian Registry for Headache Disorders (RICe).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Using a post hoc design, we evaluated 3477 patients enrolled at 30 headache centers (2019\u20132025). Patients were stratified into young adults (18\u201330\u2009years), adults (31\u201345\u2009years), middle\u2010aged (46\u201359\u2009years), and elderly individuals (\u2265\u200960\u2009years). Demographic and clinical migraine characteristics were collected. Group differences were assessed using\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      tests and Kruskal\u2013Wallis ANOVAs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 3477 patients, 644 (18.5%) were elderly, 1285 (36.9%) middle\u2010aged, 990 (28.5%) adults, and 558 (16.1%) young adults. Among migraine patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093013, 86.7%), diagnoses differed across age groups (\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      (6)\u2009=\u200971.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Elderly individuals more frequently had chronic migraine (\n                      <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\n                      ) (\n                      <jats:italic>z<\/jats:italic>\n                      \u2009=\u20094.18), whereas migraine with aura was more common in young and adult patients (\n                      <jats:italic>z<\/jats:italic>\n                      \u2009=\u20093.62 and 4.97, respectively). Medication\u2010overuse headache was more frequent in the elderly (\n                      <jats:italic>z<\/jats:italic>\n                      \u2009=\u20093.56), who reported more monthly migraine days but lower pain intensity and fewer severe attacks (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.02). Stress and physical activity were common triggers. Among patients with available treatment data, some differences in prior preventive treatment patterns were observed, with more frequent use of beta\u2010blockers and\n                      <jats:styled-content style=\"fixed-case\">onabotulinumtoxinA<\/jats:styled-content>\n                      in the elderly, whereas anti\u2010calcitonin gene\u2010related peptide (\n                      <jats:styled-content style=\"fixed-case\">CGRP<\/jats:styled-content>\n                      ) monoclonal antibody prescriptions did not differ across groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Older adults attending headache centers more frequently presented CM, with higher attack frequency, lower pain severity, greater medication overuse, and distinct triggers, supporting tailored diagnostic and therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70761","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:18:51Z","timestamp":1791983931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Migraine in Older Adults: Age\u2010Related Clinical Features From the Italian\n                    <scp>RICe<\/scp>\n                    Registry"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7760-9442","authenticated-orcid":false,"given":"Giulia","family":"Paparella","sequence":"first","affiliation":[{"name":"Neurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience University of Bari Aldo Moro  Bari Italy"},{"name":"IRCCS Neuromed  Pozzilli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3598-0195","authenticated-orcid":false,"given":"Luigi 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