{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T10:00:13Z","timestamp":1790589613881,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Continuous EEG (cEEG) is increasingly used in critically ill patients, driven by its superior seizure detection sensitivity over routine EEG (rEEG). However, cEEG is resource\u2010demanding, and whether its use translates into improved clinical outcomes in patients without primary neurologic conditions remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a post hoc analysis of the multicenter randomized CERTA trial, in which critically\u2010ill adults were randomized 1:1 to cEEG or two rEEG recordings. Six\u2010month mortality represented the primary outcome, while exploratory outcomes included functional outcome (Cerebral Performance Categories, CPC), detection of seizures\/status epilepticus, ictal\u2013interictal continuum features, medication changes, and infections within 4\u2009weeks. Analysis was restricted to patients without primary neurologic injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 364 enrolled patients, 76 lacked a primary neurologic condition (cEEG:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934, rEEG:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200942). Continuous EEG was not associated with mortality (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.970) or functional outcome (CPC 1\u20132;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.893). No seizures or status epilepticus were detected in either group. Rates of EEG periodic patterns, ictal\u2013interictal continuum features, medication changes, and infections were comparable between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In critically ill adults without a primary neurologic condition, cEEG was not associated with measurable benefits in survival, neurological recovery, or epileptiform activity detection compared with repeated rEEG, in a cohort without detected electrographic seizures or status epilepticus. Pending larger, ideally prospective comparative studies, repeated routine EEG may represent a reasonable alternative in resource\u2010limited settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70768","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:50:38Z","timestamp":1790589038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Continuous Versus Routine\n                    <scp>EEG<\/scp>\n                    in Critically Ill Patients Without Primary Neurologic Condition: Analysis of a Randomized Controlled Trial"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7241-6178","authenticated-orcid":false,"given":"Gregory","family":"Lepeu","sequence":"first","affiliation":[{"name":"Service de Neurologie, Department of Clinical Neurosciences Centre Hospitalier Universitaire Vaudois (CHUV) and Lausanne University Hospital Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Novy","sequence":"additional","affiliation":[{"name":"Service de Neurologie, Department of Clinical Neurosciences Centre Hospitalier Universitaire Vaudois (CHUV) and Lausanne University Hospital Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Service de Neurologie, Department of Clinical Neurosciences Centre Hospitalier Universitaire Vaudois (CHUV) and Lausanne University Hospital Lausanne Switzerland"},{"name":"Department of Neurology H\u00f4pital du Valais Sion Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaspar A.","family":"Schindler","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inselspital, Sleep\u2010Wake\u2010Epilepsy\u2010Center Bern University Hospital and University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5836-622X","authenticated-orcid":false,"given":"Stephan","family":"R\u00fcegg","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Basel and University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. O.","family":"Rossetti","sequence":"additional","affiliation":[{"name":"Service de Neurologie, Department of Clinical Neurosciences Centre Hospitalier Universitaire Vaudois (CHUV) and Lausanne University Hospital Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010014\u20100674\u2010y"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181a00604"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010013\u20103149\u20108"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010015\u20103709\u20101"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028\u2010019\u201000703\u2010w"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010023\u201004475\u2010w"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f07334"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.5325"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.2264"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010024\u201005246\u2010x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000125184.88797.62"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613\u2010025\u201001436\u20100"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2021.20477"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006689"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010025\u201008040\u20107"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc12899"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139969"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e3182784729"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000806"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000541335"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2022.05.017"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2012.06.010"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13447"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005311"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13510"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70768","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.70768","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70768","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:50:39Z","timestamp":1790589039000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.70768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/ene.70768"],"URL":"https:\/\/doi.org\/10.1111\/ene.70768","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,28]]},"assertion":[{"value":"2026-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70768"}}