{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:39:15Z","timestamp":1792496355279,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To address the paucity of data on outcomes and costs of status epilepticus (SE) following the updated 2015 International League Against Epilepsy (ILAE) definition and changes in clinical practice guidelines in Germany.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective population\u2010based study (October 2018\u2013March 2020) included adult patients from postal code area prefix 35, representative of Germany, diagnosed with SE according to the 2015 ILAE definition. Costs were calculated using German Diagnosis\u2010Related Groups (G\u2010DRG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 181 patients were included. Mean inpatient costs were \u20ac10,543 (median \u20ac6376; range \u20ac845\u2013\u20ac133,267), corresponding to \u20ac939 per hospital day (median \u20ac580.8; range \u20ac76.8\u2013\u20ac12,115). Mean length of stay (LOS) was 11\u2009days (median 9; range 1\u201367). In univariable analyses, super\u2010refractory SE was associated with higher costs and longer LOS (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), while acute symptomatic etiology was associated with longer LOS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). On multivariable analysis, mechanical ventilation was the strongest independent predictor of costs (Exp(B)\u2009=\u20092.918, 95% CI 1.753\u20134.857;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and etiology was overall significantly associated with cost variation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022), with acute symptomatic SE showing the highest adjusted costs. Discharge destination correlated with SE severity, with most patients with non\u2010refractory SE discharged home (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides population\u2010based data on costs and outcomes of SE in Germany, serving as a basis for future cost\u2010effectiveness analyses. Compared with earlier studies, lower direct costs and shorter LOS were observed. Identification of high\u2010risk constellations may support clinical decision\u2010making and optimize monitoring, treatment escalation, and allocation of intensive care resources.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70777","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:43:21Z","timestamp":1792493001000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prospective, Population\u2010Based Evaluation of Costs and Outcomes of Status Epilepticus According to the New Definition"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9732-3205","authenticated-orcid":false,"given":"Clara","family":"J\u00fcnemann","sequence":"first","affiliation":[{"name":"Epilepsy Center Hessen Philipps University  Marburg 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8905-3138","authenticated-orcid":false,"given":"Martin","family":"J\u00fcnemann","sequence":"additional","affiliation":[{"name":"Clinic for Neurology Justus Liebig University  Gie\u00dfen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7195-4272","authenticated-orcid":false,"given":"Christoph","family":"Best","sequence":"additional","affiliation":[{"name":"Vitos Clinic for Neurology  Weilm\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4407-1115","authenticated-orcid":false,"given":"Michael","family":"Teepker","sequence":"additional","affiliation":[{"name":"Hardtwald Clinic I for Neurology  Bad Zwesten 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8289-480X","authenticated-orcid":false,"given":"Katja","family":"Menzler","sequence":"additional","affiliation":[{"name":"Epilepsy Center Hessen Philipps University  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Timmermann","sequence":"additional","affiliation":[{"name":"Epilepsy Center Hessen Philipps University  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6298-0513","authenticated-orcid":false,"given":"Susanne","family":"Knake","sequence":"additional","affiliation":[{"name":"Epilepsy Center Hessen Philipps University  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6288-9915","authenticated-orcid":false,"given":"Adam","family":"Strzelczyk","sequence":"additional","affiliation":[{"name":"Epilepsy Center Hessen Philipps University  Marburg Germany"},{"name":"Epilepsy Center Frankfurt Rhine\u2010Main Goethe University  Frankfurt am Main Germany"},{"name":"Section Epileptology, Department of Neurology Jena University Hospital  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1046\/j.1528-1157.2001.01101.x","article-title":"Incidence of Status Epilepticus in Adults in Germany: A Prospective, Population\u2010Based Study","volume":"42","author":"Knake S.","year":"2001","journal-title":"Epilepsia"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/epi.17817","article-title":"Staged Treatment Response in Status Epilepticus: Lessons From the SENSE Registry","volume":"65","author":"Beuchat 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