{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:52:08Z","timestamp":1791359528409,"version":"4.3.1"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF\u20102016\u201002362405"],"award-info":[{"award-number":["RF\u20102016\u201002362405"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["259867"],"award-info":[{"award-number":["259867"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["101017598"],"award-info":[{"award-number":["101017598"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"HORIZON EUROPE Framework Programme","doi-asserted-by":"publisher","award":["101137074"],"award-info":[{"award-number":["101137074"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The Frontal Behavioural Inventory (FBI) was validated in behavioural\u2010variant frontotemporal dementia (bvFTD) with a cut\u2010off of 25. We tested whether this threshold is appropriate in amyotrophic lateral sclerosis (ALS), where behavioural change is milder and partly confounded by motor pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analysed 506 ALS patients with a valid FBI assessment. Behavioural impairment was defined using two complementary reference standards, to minimise dependence on any single behavioural instrument: a consensus rule (pathology on \u2265\u20092 of three independent instruments: Edinburgh Cognitive and Behavioural ALS Screen, Frontal Systems Behaviour Scale, Beaumont Behavioural Inventory) and Latent Class Analysis. ROC analysis identified the Youden\u2010optimal cut\u2010off; agreement was quantified by Cohen's\n                      <jats:italic>\u03ba<\/jats:italic>\n                      ; internal validity was assessed by stratified 5\u2010fold cross\u2010validation. Total and subscale scores were analysed separately.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 345 complete\u2010case patients, 24.6% met criteria for behavioural impairment. The FBI total discriminated impairment well (AUC 0.855, 95% CI 0.806\u20130.898). The Youden\u2010optimal cut\u2010off was FBI \u2265\u20099 (sensitivity 0.87, specificity 0.74), whereas the legacy cut\u2010off of 25 showed sensitivity 0.22. Subscale recalibration yielded cut\u2010offs of FBI\u2010Apathy \u2265\u20097 (AUC 0.808) and FBI\u2010Disinhibition \u2265\u20094 (AUC 0.851).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In ALS, the bvFTD\u2010derived threshold of 25 misses most patients with behavioural involvement. FBI \u2265\u20099 is a promising candidate ALS\u2010specific screening threshold, with scores\u2009\u2265\u200915 indicating a higher probability of behavioural involvement; exploratory subscale thresholds of \u2265\u20097 for Apathy and \u2265\u20094 for Disinhibition are also proposed. These cut\u2010offs substantially improve sensitivity while maintaining acceptable specificity, but require prospective external validation before replacing current practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70778","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:14:36Z","timestamp":1791357276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recalibration of the Frontal Behavioural Inventory Cut\u2010Off for Behavioural Screening in Amyotrophic Lateral Sclerosis"],"prefix":"10.1111","volume":"33","author":[{"given":"Barbara","family":"Iazzolino","sequence":"first","affiliation":[{"name":"\u2018Rita Levi Montalcini\u2019 Department of Neuroscience University of Turin  Turin 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