{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:03:24Z","timestamp":1791813804737,"version":"4.3.4"},"reference-count":7,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Amyloid\u2010related imaging abnormalities (ARIA) are the most relevant adverse events associated with anti\u2010amyloid therapies in Alzheimer's disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We report a case of progressive ARIA after discontinuation of lecanemab in a patient with early\u2010onset Alzheimer's disease carrying the rare APOE \u03b52\/\u03b54 genotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After two infusions, mild ARIA\u2010edema (ARIA\u2010E) and ARIA\u2010hemorrhage (ARIA\u2010H) were detected on routine MRI, prompting treatment interruption. Despite partial radiologic regression, follow\u2010up MRI 8\u2009weeks after discontinuation demonstrated marked progression with multifocal ARIA\u2010H displaying as superficial siderosis, while the patient remained clinically asymptomatic. Corticosteroid treatment was initiated and lecanemab permanently discontinued.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights that severe ARIA may progress beyond active treatment exposure and emphasizes the importance of continued MRI surveillance even after therapy cessation. Furthermore, the APOE \u03b52\/\u03b54 genotype may represent a distinct risk factor for cerebral amyloid angiopathy\u2010related vascular fragility and hemorrhagic ARIA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70779","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:26:00Z","timestamp":1791811560000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Progressive Amyloid\u2010Related Imaging Abnormalities After Discontinuation of Lecanemab in Early Alzheimer Disease in an\n                    <scp>APOE<\/scp>\n                    \u03b52\/\u03b54 Carrier"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4688-8482","authenticated-orcid":false,"given":"Elisabeth","family":"St\u00f6gmann","sequence":"first","affiliation":[{"name":"Department of Neurology Medical University of Vienna  Wien Austria"},{"name":"Comprehensive Center for Clinical Neurosciences &amp; Mental Health Medical University of Vienna  Wien Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1556-1770","authenticated-orcid":false,"given":"Lukas","family":"Haider","sequence":"additional","affiliation":[{"name":"Comprehensive Center for Clinical Neurosciences &amp; Mental Health Medical University of Vienna  Wien Austria"},{"name":"Division of General and Paediatric Radiology, Department of Biomedical Imaging and Image\u2010Guided Therapy Medical University of Vienna  Wien Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5237-4480","authenticated-orcid":false,"given":"Joel","family":"Leinkauf","sequence":"additional","affiliation":[{"name":"Comprehensive Center for Clinical Neurosciences &amp; Mental Health Medical University of Vienna  Wien Austria"},{"name":"Division of General and Paediatric Radiology, Department of Biomedical Imaging and Image\u2010Guided Therapy Medical University of Vienna  Wien Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Nakuz","sequence":"additional","affiliation":[{"name":"Comprehensive Center for Clinical Neurosciences &amp; Mental Health Medical University of Vienna  Wien Austria"},{"name":"Division of Nuclear Medicine, Department of Biomedical Imaging and Image\u2010Guided Therapy Medical University of Vienna  Wien Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5015-4718","authenticated-orcid":false,"given":"Helena","family":"Untersteiner","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Vienna  Wien Austria"},{"name":"Comprehensive Center for Clinical Neurosciences &amp; Mental Health Medical University of Vienna  Wien Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Farr","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Vienna  Wien Austria"},{"name":"Comprehensive Center for Clinical Neurosciences &amp; Mental Health Medical University of Vienna  Wien Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Silvaieh","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Vienna  Wien Austria"},{"name":"Comprehensive Center for Clinical Neurosciences &amp; Mental Health Medical University of Vienna  Wien Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6989-7539","authenticated-orcid":false,"given":"Tandis","family":"Parvizi","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Vienna  Wien Austria"},{"name":"Comprehensive Center for Clinical Neurosciences &amp; Mental Health Medical University of Vienna  Wien Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3027-7775","authenticated-orcid":false,"given":"Raphael","family":"Wurm","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Vienna  Wien Austria"},{"name":"Comprehensive Center for Clinical Neurosciences &amp; Mental Health Medical University of Vienna  Wien Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3858-3347","authenticated-orcid":false,"given":"Gregor","family":"Kasprian","sequence":"additional","affiliation":[{"name":"Comprehensive Center for Clinical Neurosciences &amp; Mental Health Medical University of Vienna  Wien Austria"},{"name":"Division of General and Paediatric Radiology, Department of Biomedical Imaging and Image\u2010Guided Therapy Medical University of Vienna  Wien Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5626-1144","authenticated-orcid":false,"given":"Thomas","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Vienna  Wien Austria"},{"name":"Comprehensive Center for Clinical Neurosciences &amp; Mental Health Medical University of Vienna  Wien Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2948-4187","authenticated-orcid":false,"given":"Ellen","family":"Gelpi","sequence":"additional","affiliation":[{"name":"Comprehensive Center for Clinical Neurosciences &amp; Mental Health Medical University of Vienna  Wien Austria"},{"name":"Division of Neuropathology and Neurochemistry, Department of Neurology Medical University of Vienna  Wien Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7570-0499","authenticated-orcid":false,"given":"Evelyn Berger","family":"Sieczkowski","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Vienna  Wien Austria"},{"name":"Comprehensive Center for Clinical Neurosciences &amp; 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