{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:02:04Z","timestamp":1791813724014,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Respiratory failure is the leading cause of death in amyotrophic lateral sclerosis (ALS). Conventional pulmonary function tests are effort\u2010dependent and may fail to detect early nocturnal hypoventilation. Transcutaneous carbon dioxide (PtcCO\n                      <jats:sub>2<\/jats:sub>\n                      ) measurement is a non\u2010invasive method for assessing ventilation, but its role in ALS remains unclear. We performed a scoping review to map the current evidence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      PubMed, Web of Science, Scopus, and Google Scholar were searched from inception to April 2026. Original studies evaluating PtcCO\n                      <jats:sub>2<\/jats:sub>\n                      monitoring in ALS were included. Due to heterogeneity in study designs, populations, and outcomes, a narrative synthesis was performed, categorized by study characteristics, measurement protocols, and clinical endpoints.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010one studies were included. Most were observational and conducted in tertiary centres. Twelve studies evaluated PtcCO\n                      <jats:sub>2<\/jats:sub>\n                      as a surrogate marker for nocturnal hypoventilation, mainly to guide initiation or titration of non\u2010invasive ventilation. Definitions of hypoventilation and reported PtcCO\n                      <jats:sub>2<\/jats:sub>\n                      metrics varied widely. Only three studies evaluated PtcCO\n                      <jats:sub>2<\/jats:sub>\n                      in relation to respiratory impairment or hypercapnia, but none reported formal measures of diagnostic accuracy. Evidence regarding the prognostic value was limited and inconsistent. Three studies showed that nocturnal hypercapnia preceded abnormalities in spirometry or daytime hypercapnia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      PtcCO\n                      <jats:sub>2<\/jats:sub>\n                      monitoring shows promise as a non\u2010invasive method for assessing nocturnal ventilatory abnormalities in ALS, including nocturnal hypoventilation. However, due to methodological heterogeneity, its diagnostic and prognostic roles remain uncertain. Current evidence is insufficient to support PtcCO\n                      <jats:sub>2<\/jats:sub>\n                      as a standalone criterion for NIV initiation. Large\u2010scale prospective studies with standardized protocols are essential to delineate its clinical utility.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70782","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:31:23Z","timestamp":1791811883000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcutaneous Carbon Dioxide Monitoring in Amyotrophic Lateral Sclerosis: A Scoping Review"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4495-6314","authenticated-orcid":false,"given":"Cl\u00e1udia","family":"Santos Silva","sequence":"first","affiliation":[{"name":"Department of Neurology Unidade Local de Sa\u00fade de Almada\u2010Seixal  Almada Portugal"},{"name":"Faculdade de Medicina Universidade de Lisboa  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7556-0158","authenticated-orcid":false,"given":"Mamede","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Universidade de Lisboa  Lisbon Portugal"},{"name":"Department of Neurosciences and Mental Health Unidade Local de Sa\u00fade de Santa Maria  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2022.2067777"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14393"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00143"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(05)70326\u20104"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2019.10.016"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.70180"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102020\u2010323810"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1958.13.3.515"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542\u2010196011000\u201000014"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1981.124.2.199"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109592.2009.02930.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/nur.0000000000000904"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf01713936"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1109\/jsen.2021.3081696"},{"issue":"11","key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1513\/AnnalsATS.202101-033CME","article-title":"Telemonitoring for Home\u2010Assisted Ventilation: A Narrative Review","volume":"18","author":"Ackrivo J.","year":"2021","journal-title":"Annals of the American Thoracic Society"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27502"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/m18\u20100850"},{"key":"e_1_2_9_19_1","first-page":"A5244","article-title":"Multicenter Study of Nocturnal Transcutaneous Carbon Dioxide Monitoring in Early\u2010Stage Amyotrophic Lateral Sclerosis","volume":"209","author":"Ackrivo J.","year":"2024","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"12","key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.4187\/respcare.10813","article-title":"Lowering PCO2 With Noninvasive Ventilation Is Associated With Improved Survival in Chronic Hypercapnic Respiratory Failure","volume":"68","author":"Jimenez J. 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