{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:41:45Z","timestamp":1792492905612,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002301","name":"Eesti Teadusagentuur","doi-asserted-by":"publisher","award":["PRG1915"],"award-info":[{"award-number":["PRG1915"]}],"id":[{"id":"10.13039\/501100002301","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intracranial vessel wall imaging (VWI) enables visualization of arterial wall pathology and may improve etiologic classification of ischemic stroke, but existing evidence is largely based on retrospective studies. We aimed to prospectively evaluate the diagnostic impact of VWI in young stroke patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this two\u2010centre study, consecutive patients aged 18\u201359\u2009years with acute ischemic stroke in the middle cerebral or anterior choroidal artery territory underwent contrast\u2010enhanced VWI within 2\u2009weeks of stroke onset. Stroke etiology was assessed using the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) and the Causative Classification of Stroke (CCS) classifications before and after incorporating VWI findings. Changes in etiologic classification and predictors of diagnostic change were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010nine patients were included (median age 53\u2009years, 72% male). Incorporation of VWI findings resulted in a change in etiologic classification in 9\/69 (13%) patients according to TOAST and 10\/69 (14%) according to CCS. For TOAST classification, the proportion of large artery atherosclerosis increased from 17% to 28%, while cryptogenic stroke decreased from 22% to 14%. Baseline cryptogenic stroke was associated with etiologic reclassification after adjustment for age and sex (OR 7.8, 95% CI: 1.2\u201349.7;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>VWI frequently identified intracranial atherosclerotic plaques not evident on luminal imaging, leading to etiologic\u00a0reclassification predominantly toward large artery atherosclerosis. These findings suggest incremental diagnostic value in the etiologic assessment of young stroke, particularly in cryptogenic cases. Larger prospective studies are warranted to determine its role in routine diagnostic algorithms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70795","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:19:45Z","timestamp":1792491585000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Impact of Intracranial Vessel Wall\n                    <scp>MRI<\/scp>\n                    on Ischemic Stroke Etiology in Young Adults"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0898-4986","authenticated-orcid":false,"given":"Juhan","family":"Reimand","sequence":"first","affiliation":[{"name":"Radiology Centre, North Estonia Medical Centre  Tallinn Estonia"},{"name":"Department of Neurology and Neurosurgery, Institute of Clinical Medicine University of Tartu  Tartu 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Medicine University of Tartu  Tartu Estonia"},{"name":"Department of Neurology North Estonia Medical Centre  Tallinn Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9383-5175","authenticated-orcid":false,"given":"Dagmar","family":"Loorits","sequence":"additional","affiliation":[{"name":"Department of Radiology Tartu University Hospital  Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7600-3024","authenticated-orcid":false,"given":"Karl","family":"J\u00f5gi","sequence":"additional","affiliation":[{"name":"Department of Neurology North Estonia Medical Centre  Tallinn Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2521-8316","authenticated-orcid":false,"given":"Teele","family":"Tuularu","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Institute of Clinical Medicine University 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