{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:46:03Z","timestamp":1760888763389},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T00:00:00Z","timestamp":1362355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p>The aim of the present study was to clarify an involvement of growth\u2010associated protein\u201043 (<jats:styled-content style=\"fixed-case\">GAP<\/jats:styled-content>\u201043) in the regeneration of primary afferent trigeminal ganglion (<jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>) neurons following inferior alveolar nerve transection (<jats:styled-content style=\"fixed-case\">IANX<\/jats:styled-content>). A larger number of <jats:styled-content style=\"fixed-case\">GAP<\/jats:styled-content>\u201043 immunoreactive (<jats:styled-content style=\"fixed-case\">GAP<\/jats:styled-content>\u201043 <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content> neurons was observed in rats 3\u00a0d after <jats:styled-content style=\"fixed-case\">IANX<\/jats:styled-content> compared with sham rats. Growth\u2010associated protein\u201043 <jats:styled-content style=\"fixed-case\">IR TG<\/jats:styled-content> neurons were also detected for 30\u00a0d after <jats:styled-content style=\"fixed-case\">IANX<\/jats:styled-content>, and the number of <jats:styled-content style=\"fixed-case\">GAP<\/jats:styled-content>\u201043 <jats:styled-content style=\"fixed-case\">IR TG<\/jats:styled-content> neurons was significantly higher in the <jats:styled-content style=\"fixed-case\">IANX<\/jats:styled-content> model until day 30. The relative number of large (&gt;600\u00a0\u03bcm<jats:sup>2<\/jats:sup>) <jats:styled-content style=\"fixed-case\">GAP<\/jats:styled-content>\u201043 <jats:styled-content style=\"fixed-case\">IR TG<\/jats:styled-content> neurons was significantly lower, whereas the relative number of small (&lt;400\u00a0\u03bcm<jats:sup>2<\/jats:sup>) <jats:styled-content style=\"fixed-case\">GAP<\/jats:styled-content>\u201043 <jats:styled-content style=\"fixed-case\">IR TG<\/jats:styled-content> neurons was significantly higher than that at day 0 until 30\u00a0d after <jats:styled-content style=\"fixed-case\">IANX<\/jats:styled-content>. To evaluate the functional recovery of damaged <jats:styled-content style=\"fixed-case\">IAN<\/jats:styled-content>, the jaw opening reflex (<jats:styled-content style=\"fixed-case\">JOR<\/jats:styled-content>), elicited by the electrical stimulation of the <jats:styled-content style=\"fixed-case\">IAN<\/jats:styled-content>, was measured before and after <jats:styled-content style=\"fixed-case\">IANX<\/jats:styled-content>. Jaw opening reflex occurrence was gradually increased and the relative threshold of electrical stimulation eliciting <jats:styled-content style=\"fixed-case\">JOR<\/jats:styled-content> was gradually decreased over the 30\u2010d duration of the study. On day 30 after <jats:styled-content style=\"fixed-case\">IANX<\/jats:styled-content>, the <jats:styled-content style=\"fixed-case\">JOR<\/jats:styled-content> occurrence and relative <jats:styled-content style=\"fixed-case\">JOR<\/jats:styled-content> threshold were similar to those in sham rats. The present findings suggest that changes in the expression of <jats:styled-content style=\"fixed-case\">GAP<\/jats:styled-content>\u201043 in <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content> neurons after <jats:styled-content style=\"fixed-case\">IANX<\/jats:styled-content> are involved in regeneration and functional recovery of the transected <jats:styled-content style=\"fixed-case\">IAN<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/eos.12021","type":"journal-article","created":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T22:03:45Z","timestamp":1362434625000},"page":"86-91","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Changes in expression of growth\u2010associated protein\u201043 in trigeminal ganglion neurons and of the jaw opening reflex following inferior alveolar nerve transection in rats"],"prefix":"10.1111","volume":"121","author":[{"given":"Kohei","family":"Teramoto","sequence":"first","affiliation":[{"name":"Department of Dysphagia Rehabilitation Nihon University School of Dentistry Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Tsuboi","sequence":"additional","affiliation":[{"name":"Department of Physiology Nihon University School of Dentistry Tokyo Japan"},{"name":"Division of Functional Morphology Dental Research Center Nihon University School of Dentistry Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamichi","family":"Shinoda","sequence":"additional","affiliation":[{"name":"Department of Physiology Nihon University School of Dentistry Tokyo Japan"},{"name":"Division of Functional Morphology Dental Research Center Nihon University School of Dentistry Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzuro","family":"Hitomi","sequence":"additional","affiliation":[{"name":"Division of Physiology Kyushu Dental University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimiko","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Dysphagia Rehabilitation Nihon University School of Dentistry Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Kaji","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Nihon University School of Dentistry Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Tamagawa","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Nihon University School of Dentistry Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azumi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry Nihon University School of Dentistry Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Noma","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Nihon University School of Dentistry Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Nihon University School of Dentistry Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Komiyama","sequence":"additional","affiliation":[{"name":"Department of Oral Function and Rehabilitation Nihon University School of Dentistry at Matsudo Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Urata","sequence":"additional","affiliation":[{"name":"Department of Complete Denture Prosthodontics Nihon University School of Dentistry Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Physiology Nihon University School of Dentistry Tokyo Japan"},{"name":"Division of Functional Morphology Dental Research Center Nihon University School of Dentistry Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2006.01623.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385198-7.00009-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-6-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.07.014"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.02.018"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.05065.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.02.023"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511401406"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2003.08.023"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)10072-2"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2658062"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.10-03-00926.1990"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90117-7"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90201-4"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-0102(97)00064-3"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(99)90284-7"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1085-9489.2003.03027.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100053798"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1085-9489.2003.03029.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.01-04-00419.1981"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(90)90155-W"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02284798"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(85)90003-7"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(84)90150-5"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(82)90063-2"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(01)00211-3"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/039139880202501109"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)50388-X"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90210-F"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90331-M"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)02889-0"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-12-134"},{"key":"e_1_2_7_34_1","first-page":"79","article-title":"Upregulation of growth associated protein 43 expression and neuronal co\u2010expression with neuropeptide Y following inferior alveolar nerve axotomy in the rat","volume":"3","author":"Khullar SM","year":"1998","journal-title":"J Peripher Nerv Syst"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903110409"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90466-9"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00794.2007"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1995.1063"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.89.1.96"},{"key":"e_1_2_7_40_1","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1523\/JNEUROSCI.08-05-01739.1988","article-title":"Neurofilament protein synthesis in DRG neurons decreases more after peripheral axotomy than after central axotomy","volume":"8","author":"Greenberg SG","year":"1988","journal-title":"J Neurosci"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.09-03-00893.1989"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902280211"}],"container-title":["European Journal of Oral Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feos.12021","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eos.12021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T11:30:38Z","timestamp":1700652638000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eos.12021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,4]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1111\/eos.12021"],"URL":"https:\/\/doi.org\/10.1111\/eos.12021","archive":["Portico"],"relation":{},"ISSN":["0909-8836","1600-0722"],"issn-type":[{"value":"0909-8836","type":"print"},{"value":"1600-0722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,4]]},"assertion":[{"value":"2012-12-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-03-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}