{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:55:32Z","timestamp":1778630132134,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T00:00:00Z","timestamp":1362355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2013,4]]},"abstract":"Interleukin (IL<\/jats:styled-content>)\u201017 is an important mediator of orthodontically induced inflammatory root resorption (OIIRR<\/jats:styled-content>). However, its role in the dental pulp (DP<\/jats:styled-content>) has not been studied. The aim of this study was to investigate, using an atopic dermatitis (AD<\/jats:styled-content>) model, how IL<\/jats:styled-content>\u201017 contributes to OIIRR<\/jats:styled-content> in DP<\/jats:styled-content>. Atopic dermatitis is the most common IL<\/jats:styled-content>\u201017\u2010associated allergic disease. Atopic dermatitis model mice (AD<\/jats:styled-content> group) and wild\u2010type mice (control group) were subjected to an excessive orthodontic force. The localization of T<\/jats:styled-content>\u2010helper (T<\/jats:styled-content>h)17 cells, IL<\/jats:styled-content>\u201017, IL\u20106, and keratinocyte chemoattractant (KC<\/jats:styled-content>; an IL\u20108\u2010related protein in rodents) were determined in DP<\/jats:styled-content>. In addition, CD<\/jats:styled-content>4+<\/jats:sup> T<\/jats:styled-content> cells, including IL<\/jats:styled-content>\u201017 production cells, were obtained from patients with AD<\/jats:styled-content> and from healthy donors, and the effects of IL<\/jats:styled-content>\u201017 on the production of IL<\/jats:styled-content>\u20106 and IL<\/jats:styled-content>\u20108 were investigated using a co\u2010culture of CD<\/jats:styled-content>4+<\/jats:sup> T<\/jats:styled-content> cells with human dental pulp (hDP<\/jats:styled-content>) cells stimulated with substance P<\/jats:styled-content> (SP<\/jats:styled-content>). Immunoreactivity for T<\/jats:styled-content>h17 cells, IL<\/jats:styled-content>\u201017, IL<\/jats:styled-content>\u20106, and KC<\/jats:styled-content> was increased in DP<\/jats:styled-content> tissue subjected to orthodontic force in the AD<\/jats:styled-content> group compared with DP<\/jats:styled-content> tissue subjected to orthodontic force in the control group. The cells obtained from the AD<\/jats:styled-content> patients displayed increased IL<\/jats:styled-content>\u20106 and IL<\/jats:styled-content>\u20108 production. These results suggest that IL<\/jats:styled-content>\u201017 may aggravate OIIRR<\/jats:styled-content> in DP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/eos.12024","type":"journal-article","created":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T22:04:05Z","timestamp":1362434645000},"page":"101-110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Interleukin\u201017\/T<\/scp>\u2010helper 17 cells in an atopic dermatitis mouse model aggravate orthodontic root resorption in dental pulp"],"prefix":"10.1111","volume":"121","author":[{"given":"Mami","family":"Shimizu","sequence":"first","affiliation":[{"name":"Department of Orthodontics Nihon University School of Dentistry at Matsudo Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Nihon University School of Dentistry at 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