{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T06:00:21Z","timestamp":1782712821134,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T00:00:00Z","timestamp":1362355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p>Oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>) is a common autoimmune inflammatory disorder that is difficult to cure, and its pathogenesis is still largely unknown. The major histocompatibility complex (<jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content>) class <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> transactivator (<jats:italic><jats:styled-content style=\"fixed-case\">CIITA<\/jats:styled-content><\/jats:italic>) gene has been reported to be an important candidate in some classical autoimmune diseases, and certain single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) in <jats:italic><jats:styled-content style=\"fixed-case\">CIITA<\/jats:styled-content><\/jats:italic> have been confirmed to be associated with susceptibility to some autoimmune diseases. We conducted this research to investigate the existence of any correlation between <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in <jats:italic><jats:styled-content style=\"fixed-case\">CIITA<\/jats:styled-content><\/jats:italic>. A case\u2013control study was performed to genotype 15 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in the <jats:italic><jats:styled-content style=\"fixed-case\">CIITA<\/jats:styled-content><\/jats:italic> gene from 42 patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> and from 86 controls; this was carried out by the <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> and then by a locus\u2010specific single\u2010base extension reaction. Allele detection was performed using matrix\u2010assisted laser desorption\/ionization time\u2010of\u2010flight (<jats:styled-content style=\"fixed-case\">MALDI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>) mass spectrometry. The <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> rs4774 variant in exon 11 (+1614<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> G<\/jats:styled-content>ly500<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>la) of <jats:italic><jats:styled-content style=\"fixed-case\">CIITA<\/jats:styled-content><\/jats:italic> is significantly associated with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> in healthy persons, both in genotype frequency and in allele frequency. Another intronic <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>, rs6498122, showed significant differences only in allele frequency. In conclusion, our data show that the two <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s rs4774 and rs6498122 are associated with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> and could also indicate the autoimmune characteristics of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/eos.12029","type":"journal-article","created":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T05:18:47Z","timestamp":1362460727000},"page":"69-75","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<i><scp>CIITA<\/scp><\/i> rs4774 and rs6498122 polymorphisms are associated with oral lichen planus in <scp>C<\/scp>hinese people: a case\u2013control study"],"prefix":"10.1111","volume":"121","author":[{"given":"Dan","family":"Wu","sequence":"first","affiliation":[{"name":"Center for DNA Typing Forth Military Medical University Xi'an 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