{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T01:38:08Z","timestamp":1784943488221,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,5,4]],"date-time":"2013-05-04T00:00:00Z","timestamp":1367625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>Orofacial clefts are a common oral disorder associated with tooth agenesis. As information on the simultaneous absence of teeth can be an aid in treatment planning, a large sample of orofacial cleft patients was examined. The sample consisted of 910 patients with cleft lip and palate. Tooth agenesis was assessed on the basis of at least two panoramic radiographs and patient records. Third\u2010molar agenesis was determined in 474 patients. Patterns of tooth agenesis were analysed using Tooth Agenesis Code (<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>) values, according to <jats:sc>van Wijk<\/jats:sc> &amp; <jats:sc>Tan<\/jats:sc>. Per quadrant, at least 90% of patients could be described according to three different patterns. In the maxilla, 85% of patients with tooth agenesis had a TAC\u2010value of 2, 16, or 18 on either the left side, right side or bilaterally. In the mandible, 90% of patients with tooth agenesis had a TAC\u2010value of 16, 1 or 2 on either the left side, right side or bilaterally. In patients with tooth agenesis, patterns were symmetrical in the maxilla in 18.8% and in the mandible in 51%. More extended cleft types were associated with a higher prevalence of tooth agenesis. Third\u2010molar agenesis (prevalence\u00a0=\u00a022.4%) was significantly related to the prevalence of other absent teeth. These results show which patterns of tooth agenesis can be expected to occur in most orofacial cleft patients.<\/jats:p>","DOI":"10.1111\/eos.12054","type":"journal-article","created":{"date-parts":[[2013,5,4]],"date-time":"2013-05-04T16:57:57Z","timestamp":1367686677000},"page":"328-332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Patterns of tooth agenesis in patients with orofacial clefts"],"prefix":"10.1111","volume":"121","author":[{"given":"Ruurd R.","family":"Hermus","sequence":"first","affiliation":[{"name":"Department of Orthodontics Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam and VU University Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjen J.","family":"van Wijk","sequence":"additional","affiliation":[{"name":"Department of Conservative and Preventive Dentistry Section of Social Dentistry Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam and VU University Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan P. K.","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam and VU University Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gem J. C.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Alkmaar Medical Centre (MCA) Alkmaar the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin M.","family":"Ongkosuwito","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Cleft Palate Team and Craniofacial Team Sophia Erasmus MC University Medical Centre Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,4]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"16","article-title":"Hypodontia in children with various types of clefts","volume":"70","author":"Shapira Y","year":"2000","journal-title":"Angle Orthod"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2006.00340.x"},{"key":"e_1_2_7_4_1","first-page":"212","article-title":"Decreasing prevalence of oral cleft live births in the Netherlands, 1997\u20132006","volume":"2011","author":"Rozendaal AM","year":"2010","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0889-5406(86)90022-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2319\/113005-419R.1"},{"key":"e_1_2_7_7_1","first-page":"1","article-title":"Dental anomalies in harelip and cleft palate","volume":"21","author":"B\u00f8hn A","year":"1963","journal-title":"Acta Odontol Scand"},{"key":"e_1_2_7_8_1","first-page":"1","article-title":"Symmetry and combinations of hypodontia in non\u2010cleft and cleft palate children","volume":"96","author":"Ranta R","year":"1988","journal-title":"Scand J Dent Res"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2009.00698.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345630420062701"},{"key":"e_1_2_7_11_1","first-page":"496","article-title":"Associations of some variables to tooth formation in children with isolated cleft palate","volume":"92","author":"Ranta R","year":"1984","journal-title":"Scand J Dent Res"},{"key":"e_1_2_7_12_1","first-page":"232","article-title":"A longitudinal radiographic study of the mineralization of 2nd premolars","volume":"85","author":"Ravn J","year":"1977","journal-title":"Scand J Dent Res"},{"key":"e_1_2_7_13_1","first-page":"14","article-title":"The relationship between third molar agenesis and reduction in tooth number","volume":"32","author":"Garn SM","year":"1962","journal-title":"Angle Orthod"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2004.00158.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569(2000)037<0017:TAUCPA>2.3.CO;2"},{"key":"e_1_2_7_16_1","first-page":"223","article-title":"Incidence of third molar development","volume":"4","author":"Banks HV","year":"1934","journal-title":"Angle Orthod"},{"key":"e_1_2_7_17_1","first-page":"750","article-title":"Our third molar teeth; their eruption. 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