{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:57:41Z","timestamp":1778637461275,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,8,9]],"date-time":"2013-08-09T00:00:00Z","timestamp":1376006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>The aim of this study was to assess whether polymorphisms in toll\u2010like receptor (<jats:italic><jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content><\/jats:italic>) and cluster of differentiation 14 (<jats:italic><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>14<\/jats:italic>) genes are associated with oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>) risk and clinical course of the disease. The study group consisted of 101 patients with confirmed <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> and 104 healthy blood donors without systemic or oral mucosal diseases. Single nucleotide polymorphisms of <jats:italic><jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>2<\/jats:italic> (rs3804099), <jats:italic><jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>3<\/jats:italic> (rs3775291 and rs5743312), <jats:italic><jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>4<\/jats:italic> (rs4986790 and rs4986791), and <jats:italic><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>14<\/jats:italic> (rs2569190) genes were genotyped using real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010restriction fragment length polymorphism (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RFLP<\/jats:styled-content>). The rs5743312 <jats:italic><jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>3<\/jats:italic> gene polymorphism was associated with increased <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> risk in comparison with the wild type genotype (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a015.984, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.011). No association with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> risk was observed for the polymorphisms studied in <jats:italic><jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>2<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>4<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>14<\/jats:italic> genes or for the rs3775291 polymorphism of the <jats:italic><jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>3<\/jats:italic> gene. The polymorphisms of the <jats:italic><jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>3<\/jats:italic> gene were in linkage disequilibrium (<jats:italic>D<\/jats:italic>\u2032\u00a0=\u00a01, <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup><jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.1). Identified haplotypes were not associated with the risk of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>. The findings of the current study suggest that the <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> genotype of the rs5743312 <jats:italic><jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>3<\/jats:italic> gene polymorphism may play a significant role in the aetiology of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/eos.12074","type":"journal-article","created":{"date-parts":[[2013,8,9]],"date-time":"2013-08-09T11:49:01Z","timestamp":1376048941000},"page":"421-426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<i><scp>TLR<\/scp>2<\/i>,<i><scp>TLR<\/scp>3<\/i>,<i><scp>TLR<\/scp>4<\/i> and <i><scp>CD<\/scp>14<\/i> gene polymorphisms associated with oral lichen planus risk"],"prefix":"10.1111","volume":"121","author":[{"given":"Dragan","family":"Stanimirovic","sequence":"first","affiliation":[{"name":"School of Dental Medicine Clinic of Periodontology and Oral Medicine University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Zeljic","sequence":"additional","affiliation":[{"name":"Institute for Medical Research Military Medical Academy Belgrade Serbia"},{"name":"Faculty of Biology University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ljiljana","family":"Jankovic","sequence":"additional","affiliation":[{"name":"School of Dental Medicine Clinic of Periodontology and Oral Medicine University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Magic","sequence":"additional","affiliation":[{"name":"School of Dental Medicine Clinic of Periodontology and Oral Medicine University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milos","family":"Hadzi\u2010Mihajlovic","sequence":"additional","affiliation":[{"name":"School of Dental Medicine Clinic of Periodontology and Oral Medicine University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zvonko","family":"Magic","sequence":"additional","affiliation":[{"name":"Institute for Medical Research Military Medical Academy Belgrade Serbia"},{"name":"Faculty of Medicine Military Medical Academy University of Defence Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,9]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"3","article-title":"Oral lichen planus: clinical features, etiology, treatment and management; a review of literature","volume":"4","author":"Boorghani M","year":"2010","journal-title":"J Dent Res Dent Clin Dent Prospects"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-009-9160-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.10.013"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01722.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-013-0920-8"},{"key":"e_1_2_7_7_1","first-page":"519","article-title":"Oral lichen planus: a review","volume":"58","author":"Carrozzo M","year":"2009","journal-title":"Minerva Stomatol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4238\/vol10-3gmr1137"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2006.01349.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2541"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-010-0208-2"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1116"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2007.05.016"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1964.0034"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm058"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12029"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12144"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2007.08.014"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2013.01.008"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-57"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.00956.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2012.02210.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-9-139"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2012.01169.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21060"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e3283101292"}],"container-title":["European Journal of Oral Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feos.12074","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eos.12074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T08:40:09Z","timestamp":1696322409000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eos.12074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,9]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1111\/eos.12074"],"URL":"https:\/\/doi.org\/10.1111\/eos.12074","archive":["Portico"],"relation":{},"ISSN":["0909-8836","1600-0722"],"issn-type":[{"value":"0909-8836","type":"print"},{"value":"1600-0722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,9]]},"assertion":[{"value":"2013-06-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-08-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}