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At baseline (2003), clinical and microbiological features were recorded in 50 patients with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>. Two microbial samples were obtained from each patient (one from a clinically healthy site and one from a periodontitis site) and these were analyzed using <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> hybridization involving 25 bacterial species. After non\u2010surgical periodontal therapy, clinical and microbiological re\u2010examinations were performed at the same or similar sites at 2\u00a0yr (2006) and 4\u00a0yr (2008) of maintenance. Plaque, bleeding on probing (BoP), and the number of sites with periodontitis (\u22654\u00a0mm) and severe periodontitis (\u22656\u00a0mm) all showed a significant decrease at 2 and 4\u00a0yr of maintenance after non\u2010surgical intervention. Checkerboard analysis revealed that various bacteria with a high colonization score (\u22653) corroborated the clinical findings of pathology at 2003, 2006, and 2008. Different clusters of bacteria, not just the \u2018red complex\u2019, were able to predict progression of chronic periodontitis during 2\u00a0yr of maintenance (2006\u20132008). Therefore, quantified bacterial markers (reflecting bacterial load) and the clinical markers BoP and periodontal probing depth show comparable prediction of future disease condition.<\/jats:p>","DOI":"10.1111\/eos.12080","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T14:20:27Z","timestamp":1378995627000},"page":"394-402","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Bacterial markers vs. clinical markers to predict progression of chronic periodontitis: a 2\u2010yr prospective observational study"],"prefix":"10.1111","volume":"121","author":[{"given":"Georgios","family":"Charalampakis","sequence":"first","affiliation":[{"name":"Department of Oral Microbiology and Immunology Institute of Odontology The Sahlgrenska Academy at the University of Gothenburg Gothenburg 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