{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T15:07:16Z","timestamp":1768489636733,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T00:00:00Z","timestamp":1379548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>Vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> acts through binding with vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> receptor (<jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content>) and is responsible for regulating bone metabolism and mineralization; it also suppresses the immune system. The aim of this study was to investigate if <jats:italic><jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content><\/jats:italic> gene polymorphisms are associated with chronic periodontitis (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>) and aggressive periodontitis (<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>) in a Jordanian population. A total of 99 patients with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>, 63 patients with <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>, and 126 controls were genotyped using <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010restriction fragment length polymorphism (<jats:styled-content style=\"fixed-case\">RFLP<\/jats:styled-content>) for <jats:italic>Bsm<\/jats:italic>I, <jats:italic>Apa<\/jats:italic>I, and <jats:italic>Taq<\/jats:italic>I single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s). The association was determined after correcting for confounding factors using multivariate logistic regression analysis. Estimation of haplotype frequencies was carried out using the <jats:styled-content style=\"fixed-case\">EH<\/jats:styled-content> program, and haplotypes were constructed using the <jats:sc>phase<\/jats:sc> 2.1 program. After correcting for confounding factors, multivariate logistic regression analysis revealed that inheritance of the <jats:italic>Bsm<\/jats:italic>I bb genotype or the <jats:italic>Apa<\/jats:italic>I aa genotype was associated with increased risk of developing <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.4 and <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a03.4, respectively) but with reduced risk of developing AgP (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.4 and <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.3, respectively). This was further supported by association of the ba haplotype with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> but not with AgP. This study supports an association of <jats:italic><jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content><\/jats:italic> gene polymorphisms with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> and AgP in a Jordanian population; however, the pattern of association was different between the two diseases.<\/jats:p>","DOI":"10.1111\/eos.12085","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T15:53:58Z","timestamp":1381247638000},"page":"551-558","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Association of vitamin <scp>D<\/scp> receptor gene polymorphisms with chronic and aggressive periodontitis in Jordanian patients"],"prefix":"10.1111","volume":"121","author":[{"given":"Jumana A.","family":"Karasneh","sequence":"first","affiliation":[{"name":"Department of Oral Medicine &amp; Oral Surgery Dental School Jordan University of Science &amp; Technology Irbid Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khansa T.","family":"Ababneh","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry Faculty of Dentistry Jordan University of Science and Technology Irbid Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anas H.","family":"Taha","sequence":"additional","affiliation":[{"name":"Private practice Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muna S.","family":"Al\u2010Abbadi","sequence":"additional","affiliation":[{"name":"Private practice Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nour al\u2010dain S.","family":"Marzouka","sequence":"additional","affiliation":[{"name":"Institute for Neurosciences of Montpellier Universit\u00e9 Montpellier 2 Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameh 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