{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T22:46:33Z","timestamp":1753051593626},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T00:00:00Z","timestamp":1410480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Provincial Nature Science Fundation of Shandong Province","award":["ZR2010HM037"],"award-info":[{"award-number":["ZR2010HM037"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>To investigate the effects of ischemia\/reperfusion on rat submandibular glands without denervation and the possible protective effects of ischemia preconditioning on the glands that experienced ischemia\/reperfusion, <jats:italic>in\u2010situ<\/jats:italic> ischemia\/reperfusion and ischemia preconditioning experimental models of submandibular glands of healthy male Wistar rats were conducted. For ischemia\/reperfusion groups, the glands were subjected to 90\u00a0min of ischemia without denervation, followed by 1, 12, 24, or 72\u00a0h of reperfusion. Ischemia preconditioning was achieved by 3\u00a0min of ischemia following 3\u00a0min of reperfusion, performed three times before ischemia\/reperfusion. Salivary secretion, histological changes, alterations of tight junctions, myeloperoxidase activity, cellular apoptosis, and reactive oxygen species levels were detected. In ischemia\/reperfusion glands, rising acute\u2010inflammation responses, reduced tight\u2010junction width, and increased myeloperoxidase activity, reactive oxygen species levels, and apoptotic cell numbers were observed, along with secretory dysfunction, especially at 1 and 12\u00a0h post\u2010reperfusion, which seemed to gradually return to normal by 72\u00a0h post\u2010reperfusion. In contrast, ischemia preconditioning showed the potential to ameliorate the injury\u2010stress responses caused by ischemia\/reperfusion. Our study revealed that ischemia\/reperfusion could cause a series of injury\u2010stress responses and ultimately lead to hyposecretion, independently of the parasympathetic nerve supply, which might play an important role in the early\u2010phase dysfunction of the transplanted glands. Ischemia preconditioning could protect the involved glands and improve ischemia\/reperfusion\u2010induced hyposecretion.<\/jats:p>","DOI":"10.1111\/eos.12149","type":"journal-article","created":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T11:45:42Z","timestamp":1410522342000},"page":"324-331","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ischemia preconditioning protects rat submandibular glands from ischemia\/reperfusion injuries"],"prefix":"10.1111","volume":"122","author":[{"given":"Liang","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery Qilu Hospital, and Institute of Dental Medicine Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery Qilu Hospital, and Institute of Dental Medicine Shandong University Jinan China"},{"name":"School of Stomatology Shandong University, and Shandong Provincial Key Laboratory of Oral Biomedicine Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei\u2010Lu","family":"Dai","sequence":"additional","affiliation":[{"name":"School of Stomatology Shandong University, and Shandong Provincial Key Laboratory of Oral Biomedicine Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao\u2010Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery Qilu Hospital, and Institute of Dental Medicine Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun\u2010Sheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery Qilu Hospital, and Institute of Dental Medicine Shandong University Jinan China"},{"name":"School of Stomatology Shandong University, and Shandong Provincial Key Laboratory of Oral Biomedicine Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng\u2010Cai","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery Qilu Hospital, and Institute of Dental Medicine Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.01.030"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.10.1279"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.9.1031"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1226(90)90009-O"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000246953.44163.81"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200009010-00004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/ijom.2002.0438"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01633.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608501208"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2006.12.005"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.10.004"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/176723"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.07.130"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.03.031"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.02.066"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2006.00411.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2012.12"},{"key":"e_1_2_7_19_1","first-page":"431","article-title":"Abnormal vascular function following ischemia\u2010reperfusion injury","volume":"43","author":"Conger JD","year":"1995","journal-title":"J Investig Med"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000107683"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1267\/ahc.05048"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.279.5.G851"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.012802"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.08.043"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2009.00975.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200106000-00030"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2006.11.021"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1089\/152308603770310266"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31816de302"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.02.035"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-009-0438-3"}],"container-title":["European Journal of Oral Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feos.12149","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eos.12149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T19:38:19Z","timestamp":1695497899000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eos.12149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,12]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/eos.12149"],"URL":"https:\/\/doi.org\/10.1111\/eos.12149","archive":["Portico"],"relation":{},"ISSN":["0909-8836","1600-0722"],"issn-type":[{"value":"0909-8836","type":"print"},{"value":"1600-0722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,12]]},"assertion":[{"value":"2014-08-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-09-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}