{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:37:56Z","timestamp":1761489476305,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangdong Provincial Science and Technology Project","award":["2012B031800036"],"award-info":[{"award-number":["2012B031800036"]}]},{"name":"he Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry","award":["2013-1792"],"award-info":[{"award-number":["2013-1792"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>This study aimed to investigate the contribution of redistributed nerves in the secretory function and regeneration of a denervated submandibular gland (<jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>). The postganglionic parasympathetic and sympathetic denervated<jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>s of rabbits were wrapped in polyester or acellular dermal matrices to block nerve regeneration either partially or completely. Submandibular glands were removed 4, 8, 16, and 24\u00a0wk after the operation and examined histologically. Furthermore, the aquaporin\u20105 (<jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>5), muscarinic\u20103 (<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>3), and \u03b21\u2010adrenergic receptors were evaluated by immunofluorescence and western blot analysis. After denervation, salivary flow was decreased and acinar cells were atrophic, and the expression levels of the<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>3, \u03b21\u2010adrenergic, and<jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>5 receptors were decreased. However, both impaired secretion function and atrophic parenchyma were gradually ameliorated with the growing redistribution of parasympathetic and sympathetic nerves. Apoptosis was markedly inhibited and expression of the<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>3, \u03b21\u2010adrenergic, and<jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>5 receptors was increased after reinnervation. In contrast,<jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>s without reinnervated nerves maintained hyposecretion and atrophic parenchyma. In conclusion, reinnervated nerves in a rabbit's denervated<jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>played an important role in the secretion function and regeneration of<jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>s via up\u2010regulation of the expression of neurotransmitter receptors and<jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>5.<\/jats:p>","DOI":"10.1111\/eos.12154","type":"journal-article","created":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T12:29:15Z","timestamp":1414844955000},"page":"372-381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Reinnervated nerves contribute to the secretion function and regeneration of denervated submandibular glands in rabbits"],"prefix":"10.1111","volume":"122","author":[{"given":"Si\u2010en","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial 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