{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:06:17Z","timestamp":1758935177494},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>This study evaluated the effect of two desensitizers on inhibition of dentin demineralization, after immersion in artificial saliva using micro\u2010computed tomography (<jats:italic>\u03bc<\/jats:italic>CT). Dentin blocks cut from bovine incisors were treated with deionized water (DW, a negative control) or one of three desensitizers: a fluoride varnish (Duraphat, a positive control), a calcium phosphate desensitizer (Teethmate Desensitizer), and a fluoro\u2010alumino\u2010calcium silicate\u2010based desensitizer (Nanoseal). After each treatment, the specimens in Duraphat, Nanoseal, and Teethmate Desensitizer groups were pre\u2010immersed in artificial saliva (<jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> 6.5) for either 1\u00a0d or 1\u00a0wk. The mineral loss of the specimens after demineralization (<jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> 5.0, 3\u00a0h) was evaluated by <jats:italic>\u03bc<\/jats:italic>CT. The treated surface was investigated with scanning electron microscopy. Mineral loss in all treatment groups was significantly lower than that in DW. Duraphat was the most effective treatment against demineralization, followed by Nanoseal. Nanoseal showed significantly better reduction in mineral loss following immersion for 1\u00a0wk in artificial saliva than for 1\u00a0d. However, Teethmate Desensitizer and Duraphat did not exhibit enhanced inhibition of demineralization over a longer period of immersion in artificial saliva. Scanning electron microscopy images showed deposition of particles on the dentin in both Teethmate Desensitizer. The application of Teethmate Desensitizer and Nanoseal to the exposed dentin surface resulted in inhibition of demineralization, with Nanoseal resulting in improved inhibition after prolonged immersion in artificial saliva.<\/jats:p>","DOI":"10.1111\/eos.12155","type":"journal-article","created":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T12:39:13Z","timestamp":1414845553000},"page":"404-410","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effect of different desensitizers on inhibition of bovine dentin demineralization: micro\u2010computed tomography assessment"],"prefix":"10.1111","volume":"122","author":[{"given":"Ena","family":"Lodha","sequence":"first","affiliation":[{"name":"Department of Cariology and Operative Dentistry Division of Oral Health Sciences Graduate School of Medical and Dental Science Tokyo Medical and Dental University (TMDU) Tokyo 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