{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T14:00:38Z","timestamp":1777039238286,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T00:00:00Z","timestamp":1432598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>The aim was to investigate how endogenous cytokine control of tumor necrosis factor (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>) influences temporomandibular joint (<jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>) pain in relation to the role of anti\u2010citrullinated peptide antibodies (<jats:styled-content style=\"fixed-case\">ACPA<\/jats:styled-content>) in patients with rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>). Twenty\u2010six consecutive patients with <jats:styled-content style=\"fixed-case\">TMJ RA<\/jats:styled-content> were included. Temporomandibular joint pain intensity was assessed at rest, on maximum mouth opening, on chewing, and on palpation. Mandibular movement capacity and degree of anterior open bite (a clinical sign of structural destruction of <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> tissues) were also assessed. Systemic inflammatory activity was assessed using the Disease Activity Score in 28 joints (<jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28) for rheumatoid arthritis. Samples of <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> synovial fluid and blood were obtained and analyzed for <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>, its soluble receptor, soluble <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> receptor <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>s<jats:styled-content style=\"fixed-case\">RII<\/jats:styled-content>), and <jats:styled-content style=\"fixed-case\">ACPA<\/jats:styled-content>. A high concentration of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> in relation to the concentration of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>s<jats:styled-content style=\"fixed-case\">RII<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> synovial fluid was associated with <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> pain on posterior palpation on maximum mouth opening. The <jats:styled-content style=\"fixed-case\">ACPA<\/jats:styled-content> concentration correlated significantly to the <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> concentration, but not to the <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>s<jats:styled-content style=\"fixed-case\">RII<\/jats:styled-content> concentration, indicating that increased inflammatory activity is mainly caused by an insufficient increase in anti\u2010inflammatory mediators. This study indicates that <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> pain on palpation in patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> is related to a deficiency in local cytokine control that contributes to increased inflammatory activity, including sensitization to mechanical stimuli over the <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/eos.12193","type":"journal-article","created":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T08:07:11Z","timestamp":1432627631000},"page":"235-241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Deficient cytokine control modulates temporomandibular joint pain in rheumatoid arthritis"],"prefix":"10.1111","volume":"123","author":[{"given":"Neveen","family":"Ahmed","sequence":"first","affiliation":[{"name":"Department of Dental Medicine Section\u00a0for Orofacial 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