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The glycosaminoglycan (<jats:styled-content style=\"fixed-case\">GAG<\/jats:styled-content>) chains covalently attached to the core protein of proteoglycans (<jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>s) provide docking sites for signaling molecules and their receptors during the morphogenesis of tissues and organs. Although <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>s are believed to play important roles in tooth formation, little is known about their exact functions in this developmental process and the relevant molecular basis. Family with sequence similarity member 20\u2010B (<jats:styled-content style=\"fixed-case\">FAM<\/jats:styled-content>20B) is a newly identified kinase that phosphorylates the xylose in the common linkage region connecting the <jats:styled-content style=\"fixed-case\">GAG<\/jats:styled-content> with the protein core of <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>s. The phosphorylation of xylose is essential for elongation of the common linkage region and the subsequent <jats:styled-content style=\"fixed-case\">GAG<\/jats:styled-content> assembly. In this study, we generated a <jats:italic>Fam20B<\/jats:italic>\u2010floxed allele in mice and found that inactivating <jats:italic>Fam20B<\/jats:italic> in the dental epithelium leads to supernumerary maxillary and mandibular incisors. This finding highlights the pivotal role of <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>s in tooth morphogenesis and opens a new window for understanding the regulatory mechanism of <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>\u2010mediated signaling cascades during tooth formation.<\/jats:p>","DOI":"10.1111\/eos.12222","type":"journal-article","created":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T14:10:13Z","timestamp":1444831813000},"page":"396-402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Inactivation of <i>Fam20B<\/i> in the dental epithelium of mice leads to supernumerary incisors"],"prefix":"10.1111","volume":"123","author":[{"given":"Ye","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences and Center for Craniofacial Research and Diagnosis Texas A&amp;M University Baylor College of Dentistry Dallas TX 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