{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:53:56Z","timestamp":1762376036341},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T00:00:00Z","timestamp":1451347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008725","name":"Agencia Nacional de Investigaci\u00f3n e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>Enamel defects in permanent and deciduous teeth may be oral manifestations of celiac disease. Sometimes they are the only sign that points to this underdiagnosed autoimmune pathology. However, the etiology of these specific enamel defects remains unknown. Based on previously reported cross\u2010reactivity of antibodies to gliadin with the enamel proteins, amelogenin and ameloblastin, we analyzed (using immunohistochemistry) the ability of anti\u2010gliadin IgG, produced during untreated disease, to recognize enamel organ structures. We used swine germ teeth as a tissue model because they are highly homologous to human teeth in terms of proteins and development biology. Strong staining of the enamel matrix and of the layer of ameloblasts was observed with serum samples from women with celiac disease; high IgG reactivity was found against both gliadin peptides and enamel matrix protein extract, but there was no IgG reactivity against tissue antigens. In line with these findings, the gamma globulin fraction from gliadin\u2010immunized BALB\/c mice showed a similar staining pattern to that of amelogenin\u2010specific staining. These results strongly suggest a pathological role for antibodies to gliadin in enamel defect dentition for both deciduous and permanent teeth, considering that IgG can be transported through the placenta during fetal tooth development.<\/jats:p>","DOI":"10.1111\/eos.12241","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T10:17:01Z","timestamp":1451384221000},"page":"11-16","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Enamel organ proteins as targets for antibodies in celiac disease: implications for oral health"],"prefix":"10.1111","volume":"124","author":[{"given":"Cecilia","family":"S\u00f3\u00f1ora","sequence":"first","affiliation":[{"name":"C\u00e1tedra de Inmunolog\u00eda Instituto de Qu\u00edmica Biol\u00f3gica Facultad de Ciencias \u2010Departamento de Biociencias Facultad de Qu\u00edmica Universidad de la Rep\u00fablica Montevideo Uruguay"},{"name":"Escuela Universitaria de Tecnolog\u00eda M\u00e9dica Facultad de Medicina. 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