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Given the fact that <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> is strongly linked to angiogenesis, anti\u2010angiogenic drugs, such as bevacizumab, might be introduced as an alternative treatment for contraindicated, non\u2010responsive patients. The aim of the present study was to report the short\u2010term effectiveness and safety of intralesional bevacizumab injection in the management of atrophic\/erosive <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>. A case series study was conducted in patients with atrophic\/erosive <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> in the buccal mucosa, assigned to receive either 2.5\u00a0mg of bevacizumab, by intralesional injection (<jats:italic>n<\/jats:italic>\u00a0=\u00a020, test), or topical 0.1% triamcinolone acetonide ointment (<jats:italic>n<\/jats:italic>\u00a0=\u00a020, control). The size, score, and pain intensity of the lesions were assessed pre\u2010 and post\u2010treatment. Tissue biopsies were collected for histopathologic, immunohistochemical, and ultrastructural examination. After 1\u00a0wk, the test group had significant reductions both in lesion seize and in pain scores compared with controls. A marked decrease in vascular endothelial growth factor (<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>) and interleukin\u20108 immunoexpression was noted in tissue biopsies from bevacizumab\u2010treated lesions compared with control lesions. Furthermore, ultrastructural examination of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> tissue specimens revealed significant healing signs associated with bevacizumab treatment. Short\u2010term data suggest that intralesional bevacizumab injection effectively and safely achieved resolution of atrophic\/erosive <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> lesions without disease exacerbations during a 3\u2010month follow\u2010up period.<\/jats:p>","DOI":"10.1111\/eos.12251","type":"journal-article","created":{"date-parts":[[2016,2,20]],"date-time":"2016-02-20T14:49:50Z","timestamp":1455979790000},"page":"119-126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Anti\u2010angiogenic therapy (bevacizumab) in the management of oral lichen planus"],"prefix":"10.1111","volume":"124","author":[{"given":"Maha M.","family":"Mahmoud","sequence":"first","affiliation":[{"name":"Oral Medicine Periodontology Radiology and Diagnosis Faculty of Dentistry Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa M.","family":"Afifi","sequence":"additional","affiliation":[{"name":"Oral Pathology Faculty of Dentistry Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2004.00221.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-962X.151692"},{"key":"e_1_2_7_4_1","first-page":"151","article-title":"Effect of cedar honey in the treatment of oral lichen planus","volume":"26","author":"Sanatkhani M","year":"2014","journal-title":"Iran J Otorhinolaryngol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-007-9074-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.14.e558"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.04.020"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-011-0150-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-007-9083-1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-007-0632-x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2007.03.035"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03923.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2741\/e712"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962011000400002"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568010043483881"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21588"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.51.193"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2006.05.023"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.05.132"},{"key":"e_1_2_7_20_1","first-page":"455","article-title":"Adeno\u2010associated virus vector\u2010mediated anti\u2010angiogenic gene therapy for collagen\u2010induced arthritis in mice","volume":"23","author":"Takahashi H","year":"2005","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1997.4479"},{"key":"e_1_2_7_22_1","first-page":"964","article-title":"The effect of thalidomide and 2 analogs on collagen induced arthritis","volume":"25","author":"Oliver SJ","year":"1998","journal-title":"J Rheumatol"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200009)43:9<2056::AID-ANR17>3.0.CO;2-2"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.5.607"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-6-713"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-011-0720-z"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986706777585059"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2012.0202"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/19854"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1726-4901(08)70048-0"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2013.07.023"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/15.3.185"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1992.tb00974.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2010.2876"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1102673"},{"key":"e_1_2_7_36_1","unstructured":"KirkpatrickLA FeeneyBC.A simple guide to IBM SPSS statistics: for version 20.0. 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