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The aim of this study was to assess the expression of <jats:styled-content style=\"fixed-case\">SFRP<\/jats:styled-content>1 in the invasive front of tongue squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>). Immunohistochemical expression of <jats:styled-content style=\"fixed-case\">SFRP<\/jats:styled-content>1 in the cohesive and discohesive invasive front of 36 resection specimens of tongue <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> was investigated. Immunostaining was compared with tumour size, tumour thickness, and neural invasion. Immunoreactivity increased in depth from the surface of the tumour to the invasive front. There was a statistically significant association between type of invasive front and pattern of <jats:styled-content style=\"fixed-case\">SFRP<\/jats:styled-content>1 expression. A discohesive invasive front showed more intense immunoreactivity. No statistically significant associations were found between the intensity of staining and relevant prognostic factors. Tongue <jats:styled-content style=\"fixed-case\">SSC<\/jats:styled-content> has variable <jats:styled-content style=\"fixed-case\">SFRP<\/jats:styled-content>1 expression in different parts of the tumour and the greatest expression is in the invasive front. The more intense staining in the discohesive invasive front compared with the cohesive invasive front might contribute to the worse prognosis of cancers with a discohesive invasive front.<\/jats:p>","DOI":"10.1111\/eos.12252","type":"journal-article","created":{"date-parts":[[2016,2,27]],"date-time":"2016-02-27T14:42:02Z","timestamp":1456584122000},"page":"158-163","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immunohistochemical expression of secreted frizzled receptor protein 1 in the invasive front of tongue squamous cell carcinoma"],"prefix":"10.1111","volume":"124","author":[{"given":"Siavash","family":"Rahimi","sequence":"first","affiliation":[{"name":"Pathology Centre\u2010Histopathology Queen Alexandra Hospital Portsmouth UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Kenward","sequence":"additional","affiliation":[{"name":"Pathology Centre\u2010Histopathology Queen 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