{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T02:41:40Z","timestamp":1781664100162,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,4,5]],"date-time":"2016-04-05T00:00:00Z","timestamp":1459814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>Inferior alveolar nerve (<jats:styled-content style=\"fixed-case\">IAN<\/jats:styled-content>) injury, which is frequently caused by orofacial surgery or trauma, induces sensory loss in orofacial regions innervated by the <jats:styled-content style=\"fixed-case\">IAN<\/jats:styled-content>. However, no effective treatment for orofacial sensory loss currently exists. We determined whether sensory loss in facial skin above the mental foramen following <jats:styled-content style=\"fixed-case\">IAN<\/jats:styled-content> transection was recovered by exposure of the transected <jats:styled-content style=\"fixed-case\">IAN<\/jats:styled-content> to low\u2010intensity pulsed ultrasound (<jats:styled-content style=\"fixed-case\">LIPUS<\/jats:styled-content>). Inferior alveolar nerve transection (IANX) was performed in 7\u2010wk\u2010old male Sprague\u2010Dawley rats. On day 7 after <jats:styled-content style=\"fixed-case\">IANX<\/jats:styled-content>, the effect of daily <jats:styled-content style=\"fixed-case\">LIPUS<\/jats:styled-content> (from day 0) on the transected <jats:styled-content style=\"fixed-case\">IAN<\/jats:styled-content>, in terms of sensitivity to mechanical stimulation of the facial skin above the mental foramen, was examined. Moreover, the number of trigeminal ganglion (<jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>) neurons innervating the facial skin above the mental foramen of rats with <jats:styled-content style=\"fixed-case\">IANX<\/jats:styled-content> treated daily with <jats:styled-content style=\"fixed-case\">LIPUS<\/jats:styled-content> was counted using the retrograde neurotracing technique. Daily exposure of the transected <jats:styled-content style=\"fixed-case\">IAN<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">LIPUS<\/jats:styled-content> significantly promoted recovery of the head\u2010withdrawal threshold in response to mechanical stimulation of the facial skin above the mental foramen, and the number of <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content> neurons innervating the facial skin above mental foramen was significantly increased in rats with <jats:styled-content style=\"fixed-case\">IANX<\/jats:styled-content> treated daily with <jats:styled-content style=\"fixed-case\">LIPUS<\/jats:styled-content> compared with sham or <jats:styled-content style=\"fixed-case\">LIPUS<\/jats:styled-content>\u2010unexposed rats. Daily treatment of stumps of the transected <jats:styled-content style=\"fixed-case\">IAN<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">LIPUS<\/jats:styled-content> facilitated morphological and functional regeneration, suggesting that <jats:styled-content style=\"fixed-case\">LIPUS<\/jats:styled-content> is an effective and novel therapy for <jats:styled-content style=\"fixed-case\">IAN<\/jats:styled-content> injury.<\/jats:p>","DOI":"10.1111\/eos.12271","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T12:22:55Z","timestamp":1460290975000},"page":"246-250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Low\u2010intensity pulsed ultrasound accelerates nerve regeneration following inferior alveolar nerve transection in rats"],"prefix":"10.1111","volume":"124","author":[{"given":"Mai","family":"Sato","sequence":"first","affiliation":[{"name":"Department 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