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In this study, it was evaluated whether this increased risk remains when Amerindian ancestry is estimated using autosomal markers and considered in the predictive model. Ancestry was estimated through genotyping 62 insertion and deletion (<jats:styled-content style=\"fixed-case\">INDEL<\/jats:styled-content>) markers in sample sets of patients with <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u00b1P, patients with cleft palate (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>), and controls, from Patagonia in southern Argentina and Bel\u00e9m in northern Brazil. The Amerindian ancestry in patients from Patagonia with <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u00b1P was greater than in controls although it did not reach statistical significance. The European ancestry in patients with <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u00b1P from Bel\u00e9m and in patients with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> from Bel\u00e9m and Patagonia was higher than in controls and statistically significant for patients with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> who were from Bel\u00e9m. This high contribution of European genetic ancestry among patients with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> who were from Bel\u00e9m has not been previously observed in American populations. Our results do not corroborate the currently accepted risks for <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u00b1P and <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> estimated by epidemiological studies in the North American populations and probably reflect the higher admixture found in South American ethnic groups when compared with the same ethnic groups from the North American populations.<\/jats:p>","DOI":"10.1111\/eos.12275","type":"journal-article","created":{"date-parts":[[2016,4,23]],"date-time":"2016-04-23T08:30:21Z","timestamp":1461400221000},"page":"406-411","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Analysis of the genetic ancestry of patients with oral clefts from South American admixed populations"],"prefix":"10.1111","volume":"124","author":[{"given":"Camilla D.","family":"Vieira\u2010Machado","sequence":"first","affiliation":[{"name":"ECLAMC at 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