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This study evaluated the effect of parasympathectomy on salivary secretion from normal and irradiated rat<jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>s from 1 to 24 wk after denervation. Although stimulated salivary secretion was significantly lower in denervated<jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>s compared with contralateral self\u2010controls, the resting salivary flow rates were markedly higher in the denervated<jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>s at 1, 12, and 24 wk after denervation. The levels of muscarinic acetylcholine M1 and M3 receptors, as well as of aquaporin 5, were up\u2010regulated. Notably, although irradiated<jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>s showed significantly lower resting and stimulated salivary secretion rates than non\u2010irradiated<jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>s, the resting salivary secretion rates of the irradiated and denervated<jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>s were markedly higher than seen in the irradiated self\u2010control<jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>s at 1, 12, and 24 wk after parasympathectomy, and were even higher than seen in the non\u2010irradiated sham\u2010operated rats. The expression of M1 and M3 receptors was similarly elevated. Taken together, our results suggest that parasympathetic denervation increases resting salivary secretion of both normal and irradiated<jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>s. This approach might provide a potential modality for relieving radiation\u2010induced xerostomia, which is a common complication following treatment of head and neck cancer.<\/jats:p>","DOI":"10.1111\/eos.12330","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T19:16:33Z","timestamp":1484334993000},"page":"110-118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Parasympathectomy increases resting salivary secretion in normal and irradiated submandibular glands of rats"],"prefix":"10.1111","volume":"125","author":[{"given":"Wei","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery National Engineering Laboratory for Digital and Material Technology of Stomatology Peking University School and Hospital of Stomatology Beijing China"},{"name":"Beijing Key Laboratory of Digital Stomatology Beijing 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