{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:20:57Z","timestamp":1787224857648,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T00:00:00Z","timestamp":1498176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>This clinical study aimed to determine whether periodontal disease is associated with expression of developmental endothelial locus\u20101 (Del\u20101) and pentraxin\u20103 (<jats:styled-content style=\"fixed-case\">PTX<\/jats:styled-content>\u20103), endogenous inhibitors of leukocyte extravasation in humans. Expression of <jats:italic>DEL1<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">PTX<\/jats:styled-content>3<\/jats:italic>, interleukin\u201017A (<jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17A<\/jats:italic>), and lymphocyte function\u2010associated antigen\u20101 (<jats:italic><jats:styled-content style=\"fixed-case\">LFA<\/jats:styled-content>1<\/jats:italic>) was determined, using RT\u2010PCR and melting curve analysis, in biopsies of gingival tissues from 95 patients: 42 with moderate periodontitis; 40 with severe periodontitis; and 13 healthy controls. Relative expression of <jats:italic>DEL1<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">PTX<\/jats:styled-content>3<\/jats:italic> was statistically significantly weaker in patients with periodontitis than in the control subjects. On the contrary, both <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17A<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">LFA<\/jats:styled-content>1<\/jats:italic> showed statistically significant stronger expression in patients with periodontitis than in healthy controls. Correlation analysis, performed using Spearman's test, showed that expression of <jats:italic>DEL1<\/jats:italic> was statistically significantly linked to periodontitis (<jats:italic>\u03c1<\/jats:italic> = \u22120.103) and to age (<jats:italic>\u03c1<\/jats:italic> = \u22120.134), but not to the gender of the patient, and that expression of <jats:italic><jats:styled-content style=\"fixed-case\">PTX<\/jats:styled-content>3<\/jats:italic> was significantly correlated with periodontitis (<jats:italic>\u03c1<\/jats:italic> = \u22120.354). Expression of neutrophil extravasation inhibitors <jats:italic>DEL1<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">PTX<\/jats:styled-content>3<\/jats:italic> show significant, but weak, association with the clinical manifestation of chronic periodontitis.<\/jats:p>","DOI":"10.1111\/eos.12357","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T06:30:46Z","timestamp":1498199446000},"page":"258-264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Clinical association between chronic periodontitis and the leukocyte extravasation inhibitors developmental endothelial locus\u20101 and pentraxin\u20103"],"prefix":"10.1111","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4708-784X","authenticated-orcid":false,"given":"Matthias","family":"Folwaczny","sequence":"first","affiliation":[{"name":"Department of Operative Dentistry and Periodontology 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