{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:29:16Z","timestamp":1781659756179,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:00:00Z","timestamp":1507680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K21410 and 17K11855"],"award-info":[{"award-number":["15K21410 and 17K11855"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007854","name":"School of Dentistry, Nihon University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007854","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>The P2Y<jats:sub>12<\/jats:sub> receptor expressed in satellite cells of the trigeminal ganglion is thought to contribute to neuropathic pain. The functional interaction between neurons and satellite cells via P2Y<jats:sub>12<\/jats:sub> receptors and phosphorylated extracellular signal\u2010regulated kinase 1\/2 (<jats:styled-content style=\"fixed-case\">pERK<\/jats:styled-content>1\/2) underlying neuropathic pain in the tongue was evaluated in this study. Expression of P2Y<jats:sub>12<\/jats:sub> receptor was enhanced in <jats:styled-content style=\"fixed-case\">pERK<\/jats:styled-content>1\/2\u2010immunoreactive cells encircling trigeminal ganglion neurons after lingual nerve crush. The administration to lingual nerve crush rats of a selective P2Y<jats:sub>12<\/jats:sub> receptor antagonist, <jats:styled-content style=\"fixed-case\">MRS<\/jats:styled-content>2395, attenuated tongue hypersensitivity to mechanical and heat stimulation and suppressed the increase in the relative numbers of calcitonin gene\u2010related peptide (<jats:styled-content style=\"fixed-case\">CGRP<\/jats:styled-content>)\u2010immunoreactive neurons and neurons encircled by <jats:styled-content style=\"fixed-case\">pERK<\/jats:styled-content>1\/2\u2010immunoreactive cells. Administration of the P2Y<jats:sub>1,12,13<\/jats:sub> receptor agonist, 2\u2010(methylthio)adenosine 5\u2032\u2010diphosphate trisodium salt hydrate (2\u2010Me<jats:styled-content style=\"fixed-case\">SADP<\/jats:styled-content>), to na\u00efve rats induced neuropathic pain in the tongue, as in lingual nerve crush rats. Co\u2010administration of 2\u2010Me<jats:styled-content style=\"fixed-case\">SADP<\/jats:styled-content> + <jats:styled-content style=\"fixed-case\">MRS<\/jats:styled-content>2395 to na\u00efve rats did not result in hypersensitivity of the tongue. The relative number of <jats:styled-content style=\"fixed-case\">CGRP<\/jats:styled-content>\u2010immunoreactive neurons increased following this co\u2010administration, but to a lesser degree than observed in 2\u2010MeSADP\u2010administrated na\u00efve rats, and the relative number of neurons encircled by <jats:styled-content style=\"fixed-case\">pERK<\/jats:styled-content>1\/2\u2010immunoreactive cells did not change. These results suggest that the interaction between activated satellite cells and <jats:styled-content style=\"fixed-case\">CGRP<\/jats:styled-content>\u2010immunoreactive neurons via P2Y<jats:sub>12<\/jats:sub> receptors contributes to neuropathic pain in the tongue associated with lingual nerve injury.<\/jats:p>","DOI":"10.1111\/eos.12382","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T10:08:36Z","timestamp":1507716516000},"page":"444-452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Interaction between calcitonin gene\u2010related peptide\u2010immunoreactive neurons and satellite cells via P2Y<sub>12<\/sub>R in the trigeminal ganglion is involved in neuropathic tongue pain in rats"],"prefix":"10.1111","volume":"125","author":[{"given":"Shiori","family":"Sugawara","sequence":"first","affiliation":[{"name":"Department of Physiology Nihon University School of Dentistry 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