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The aim of this study was to assess the ability of the novel\u2010<jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content> to close the experimental gaps at the dentin\u2013cement interface. The novel\u2010<jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content> was tested against Vitrebond and <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> Fuji <jats:styled-content style=\"fixed-case\">II LC<\/jats:styled-content>. Experimental gaps of 50 or 300\u00a0<jats:italic>\u03bc<\/jats:italic>m width were created between the materials and dentin. Specimens with the 300\u2010<jats:italic>\u03bc<\/jats:italic>m\u2010wide gap were immersed in phosphate\u2010buffered saline and the closed gap area was measured during 96 h. All specimens with 50 or 300\u00a0<jats:italic>\u03bc<\/jats:italic>m gap width were analyzed by scanning electron microscopy equipped with energy dispersive X\u2010ray spectroscopy (<jats:styled-content style=\"fixed-case\">SEM<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EDX<\/jats:styled-content>) to assess the morphology and chemical composition of the precipitates after 96\u00a0h immersion in phosphate\u2010buffered saline. High\u2010resolution micro\u2010computed tomography (<jats:italic>\u03bc<\/jats:italic>CT) was used to evaluate the integrity and continuity of the precipitiates after 96\u00a0h and 180\u00a0d. In all novel\u2010<jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content> samples, precipitates closed the gap area completely after 96\u00a0h. The <jats:styled-content style=\"fixed-case\">SEM<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EDX<\/jats:styled-content> revealed that the globular precipitates closing the gap area were mainly composed of calcium and phosphorus. After 180\u00a0d, <jats:italic>\u03bc<\/jats:italic>CT indicated thicker precipitates compared with initial precipitates only in the novel\u2010<jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content> group, whereas no precipitates were observed in resin\u2010modified glass ionomers. Novel\u2010<jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content> promoted continuous precipitation of calcium phosphate, including apatite, and closed the experimental gaps.<\/jats:p>","DOI":"10.1111\/eos.12399","type":"journal-article","created":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T11:08:59Z","timestamp":1516014539000},"page":"118-125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Calcium phosphate precipitation in experimental gaps between fluoride\u2010containing fast\u2010setting calcium silicate cement and dentin"],"prefix":"10.1111","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0919-5145","authenticated-orcid":false,"given":"Bahram","family":"Ranjkesh","sequence":"first","affiliation":[{"name":"Department of Dentistry and Oral Health Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery &amp; Traumatology Odense University Hospital Institute of Clinical Research University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Dalstra","sequence":"additional","affiliation":[{"name":"Department of Dentistry and Oral Health Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens R.","family":"Nyengaard","sequence":"additional","affiliation":[{"name":"Stereology and Electron Microscopy Laboratory Centre for Stochastic Geometry and Advanced Bioimaging Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Chevallier","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flemming","family":"Isidor","sequence":"additional","affiliation":[{"name":"Department of Dentistry and Oral Health Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"L\u00f8vschall","sequence":"additional","affiliation":[{"name":"Department of Dentistry and Oral Health Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,15]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"77","article-title":"Systematic reviews: I. 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