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Here, a meta\u2010analysis was conducted to assess their associations. A systematic search of PubMed to 1 September 2017, was performed to retrieve all eligible studies. Odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s) were used to calculate the associations. The stability of the results was evaluated by sensitivity analysis. Publication bias was assessed using Begg's funnel plots and the Egger test. In silico <jats:italic>Msx1<\/jats:italic> expression during early mouse craniofacial development was evaluated by the Gene Expression Omnibus. In the overall analysis, <jats:italic><jats:styled-content style=\"fixed-case\">MSX<\/jats:styled-content>1<\/jats:italic> rs12532 (G&gt;A) contributed to a decreased risk of <jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content>. In an analysis stratified according to disease type, rs12532 was associated with the risk of cleft palate only (<jats:styled-content style=\"fixed-case\">CPO<\/jats:styled-content>) but not with the risk of cleft lip with or without cleft palate (<jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\/P). The association of rs12532 with the occurrence of <jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content> in Asian and Caucasian populations but not South American populations was observed in an analysis stratified according to ethnicity. However, no significant associations were detected between any of the other <jats:italic><jats:styled-content style=\"fixed-case\">MSX<\/jats:styled-content>1 <\/jats:italic><jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s and the risk of <jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content> in either the overall or subgroup analysis. The <jats:italic>Msx1<\/jats:italic> gene was widely expressed in mouse craniofacial structures from embryonic day (E)8.5\u2010E10.5. Taken together, the study indicates that <jats:italic><jats:styled-content style=\"fixed-case\">MSX<\/jats:styled-content>1<\/jats:italic> rs12532 is associated with the risk of NSOC.<\/jats:p>","DOI":"10.1111\/eos.12414","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T11:45:41Z","timestamp":1523965541000},"page":"180-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<scp>MSH<\/scp> homeobox 1 polymorphisms and the risk of non\u2010syndromic orofacial clefts: a meta\u2010analysis"],"prefix":"10.1111","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0230-576X","authenticated-orcid":false,"given":"Min","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Dentistry The Third Affiliated Hospital of Soochow University The First People's Hospital of Changzhou Changzhou 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of Soochow University The First People's Hospital of Changzhou Changzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dentistry The Third Affiliated Hospital of Soochow University The First People's Hospital of Changzhou Changzhou 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