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Cleidocranial dysplasia (<jats:styled-content style=\"fixed-case\">CCD<\/jats:styled-content>), caused by mutations in the runt\u2010related transcription factor 2 (<jats:italic><jats:styled-content style=\"fixed-case\">RUNX<\/jats:styled-content>2<\/jats:italic>) gene, is such a condition. The dental phenotype includes problems in both tooth formation (multiple supernumerary permanent teeth) and tooth eruption (lack of shedding of primary teeth and delayed or arrested eruption of permanent teeth). Clinical studies, animal models, and molecular biology studies have documented that <jats:italic><jats:styled-content style=\"fixed-case\">RUNX<\/jats:styled-content>2<\/jats:italic> is of paramount importance for osteoblast differentiation, for regression of the dental lamina, and for osteoclastogenesis in the dental follicle and the periodontal ligament. <jats:sc>Jensen<\/jats:sc> &amp; <jats:sc>Kreiborg<\/jats:sc>, 25\u00a0yr ago, proposed a treatment strategy to be applied to patients with <jats:styled-content style=\"fixed-case\">CCD<\/jats:styled-content>, focussing on the importance of early treatment to promote spontaneous eruption of permanent teeth through extraction of primary teeth, surgical removal of supernumerary teeth, and removal of bone covering the first formed permanent teeth at the time when root formation of the permanent teeth has reached half or two\u2010thirds of their final length. This strategy still seems valid and seems to lead to reduction in the burden of care for patients compared with the treatment protocols otherwise recommended.<\/jats:p>","DOI":"10.1111\/eos.12418","type":"journal-article","created":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T05:15:41Z","timestamp":1536038141000},"page":"72-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Tooth formation and eruption \u2013 lessons learnt from cleidocranial dysplasia"],"prefix":"10.1111","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5151-8270","authenticated-orcid":false,"given":"Sven","family":"Kreiborg","sequence":"first","affiliation":[{"name":"Section\u00a0of Pediatric Dentistry and Clinical Genetics Department of Odontology Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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