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This study evaluated the biocompatibility and biomineralization of this new MTA material and compared it with that of two other MTA cements over time. Tubes containing materials (or empty tubes as controls) were inserted into the subcutaneous tissues of 40 rats. On days 7, 15, 30, 60, and 90, the tubes were removed with the surrounding tissues, which were either stained with haematoxylin and eosin or von Kossa for further analyses or unstained for observation under polarized light. On days 7 and 15, moderate inflammation was observed in most specimens, and the fibrous capsule was thick. On day 30, there was mild inflammation in all groups, and the fibrous capsule was thin. On days 60 and 90, there was mild inflammation in the material groups, while the control group showed no inflammation, although no statistically significant difference between the groups was observed and the fibrous capsule was thin. All material groups showed structures that stained with von Kossa and could be observed under polarized light; this was not found for the control. In conclusion, the new MTA material had biocompatibility and biomineralization properties similar to those of the two existing MTA materials.<\/jats:p>","DOI":"10.1111\/eos.12539","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T02:50:40Z","timestamp":1530499840000},"page":"326-333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["In vivo biocompatibility and biomineralization of calcium silicate cements"],"prefix":"10.1111","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5459-353X","authenticated-orcid":false,"given":"Francine","family":"Benetti","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry, Endodontics School of Dentistry S\u00e3o Paulo State University (Unesp) Ara\u00e7atuba SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o E.","family":"Gomes\u2010Filho","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Endodontics School of Dentistry S\u00e3o Paulo State University (Unesp) Ara\u00e7atuba SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana M.","family":"de Ara\u00fajo Lopes","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Endodontics School of Dentistry S\u00e3o Paulo State University (Unesp) Ara\u00e7atuba SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica G.","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Endodontics School of Dentistry S\u00e3o Paulo State University (Unesp) Ara\u00e7atuba SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rog\u00e9rio C.","family":"Jacinto","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Endodontics School of Dentistry S\u00e3o Paulo State University (Unesp) Ara\u00e7atuba SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano T. 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