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Single motor unit (SMU) activity was recorded at two sites within the right masseter [superior\/anterior, inferior\/posterior (IP)] during isometric biting tasks (ramp, step level) on an intraoral force transducer in 17 participants during three experimental blocks comprising no infusion (baseline), 5% hypertonic saline infusion (pain), or isotonic saline infusion (control). A visual analog scale (VAS) was used to score pain intensity. The VAS scores were statistically significantly greater during infusion of hypertonic saline than during infusion of isotonic saline. No significant differences in force levels and rates of force change were found between experimental blocks. In comparison with isotonic saline infusion, SMUs could be recruited and derecruited at both sites during hypertonic saline infusion. The frequency of recruitment or derecruitment, in comparison with no change, was statistically significantly greater at the IP site than at the superior\/anterior site. Experimental noxious masseter stimulation results in a reorganization of motor unit activity throughout the muscle, and the pattern of reorganization may be different in different regions of the muscle.<\/jats:p>","DOI":"10.1111\/eos.12561","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T12:54:37Z","timestamp":1532955277000},"page":"400-410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Reorganization of motor unit activity at different sites within the human masseter muscle during experimental masseter pain"],"prefix":"10.1111","volume":"126","author":[{"given":"Bushra","family":"Malik","sequence":"first","affiliation":[{"name":"Jaw Function and Orofacial Pain Research Unit Faculty of Dentistry Westmead Hospital Centre for Oral Health University of Sydney Westmead 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