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High mobility group protein B1 was recently shown to be involved in tooth movement. Here, we investigated the expression of <jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>1, which remains poorly elucidated, under stress overload\u2010induced periodontal remodelling conditions in vivo. Thirty\u2010six Sprague\u2010Dawley rats (male, 180\u2013200\u00a0g) were randomly divided into three groups: two experimental groups, in which 50 or 100\u00a0g of force was applied to the first molars for 7\u00a0d to induce movement; and one control group, in which no force was applied. These stresses induced tooth movement over significantly different distances, and marked morphological changes were consistently observed in the periodontal tissues of the experimental rats, as demonstrated by histological staining. A real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> analysis showed upregulation of the receptor activator of nuclear factor\u2010kappaB ligand\u2010to\u2010osteoprotegerin ratio and downregulation of the <jats:italic><jats:styled-content style=\"fixed-case\">Hmgb<\/jats:styled-content>1<\/jats:italic> gene. Changes in both location and expression of the <jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>1 were observed through immunofluorescence analysis. Our data suggest that <jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>1 expression during orthodontic tooth movement might be regulated in a time\u2010 and force\u2010dependent manner that is substantially more complex than anticipated.<\/jats:p>","DOI":"10.1111\/eos.12644","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T10:20:56Z","timestamp":1566987656000},"page":"396-407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Stress overload\u2010induced periodontal remodelling coupled with changes in high mobility group protein B1 during tooth movement: an in\u2010vivo study"],"prefix":"10.1111","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4246-1783","authenticated-orcid":false,"given":"Yuchun","family":"Zou","sequence":"first","affiliation":[{"name":"Orthodontics Department School and Hospital of Stomatology Fujian Medical University 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