{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T23:06:10Z","timestamp":1769727970587,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T00:00:00Z","timestamp":1628035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fascin 1 plays important pro\u2010metastatic roles in head and neck carcinoma (HNSCC) migration, invasion, and metastasis. However, limited advancement in targeting metastasis remains a major obstacle in improving HNSCC patients\u2019 survival. Therefore, we assessed the therapeutic potential of fascin 1 targeted inhibition and its potential prognostic value in HNSCC patients. Using in vitro and in vivo approaches, we investigated the effect of compound G2, a novel fascin 1 inhibitor, on HNSCC cells migration, invasion, and metastasis. High\u2010throughput screening (HTS) was used to assess cytotoxic activity of compound G2 alone or combined with irradiation. We also evaluated the prognostic potential of fascin 1 in HNSCC patients. Interestingly, compound G2 reduced carcinoma cells migration and invasion in vitro and inhibited metastasis in vivo. Moreover, HTS revealed a modest cytotoxic activity of the compound G2 on HNSCC cell lines. Irradiation did not synergistically enhance the compound G2\u2010mediated cytotoxic activity. Survival analyses showed that high fascin 1 immunoexpression, at the tumor invasive front, was associated with cancer\u2010specific mortality in the advanced stages of HNSCC. Collectively, our findings suggest that fascin 1 represents a promising anti\u2010metastatic therapeutic target and a useful prognostic marker in patients with HNSCC. Novel anti\u2010metastatic agents could provide a valuable addition to cancer therapy.<\/jats:p>","DOI":"10.1111\/eos.12819","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T11:51:01Z","timestamp":1628077861000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The effect of fascin 1 inhibition on head and neck squamous cell carcinoma cells"],"prefix":"10.1111","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6716-8113","authenticated-orcid":false,"given":"Awais","family":"Wahab","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases Clinicum University of Helsinki  Helsinki Finland"},{"name":"Translational Immunology Program Faculty of Medicine University of Helsinki  Helsinki 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