{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:20:57Z","timestamp":1776918057801,"version":"3.51.2"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cleft lip and\/or palate (CL\/P), the most prevalent congenital anomaly, is understood to negatively affect a wide range of child development. Since the concept remains controversial, because most published work is from cross\u2010sectional studies, we examined the neurodevelopmental trajectories in participants with CL\/P through a longitudinal comparison with the general population during early childhood using data from a nationwide birth cohort study in Japan. The linear mixed models for each domain of the Ages and Stages Questionnaire, third edition (ASQ\u20103), were used to detect differences in standardised mean scores between groups. The ASQ\u20103 is a general neurodevelopmental screening tool comprising communication, gross motor, fine motor, problem\u2010solving, and personal\u2010social domains. Participants\u2019 neurodevelopment was determined semi\u2010annually from 6 to 36 months of age. The trajectories of standardised mean scores in each domain showed several significant differences between the control and CL\/P groups, with the maximum difference at 24 months of age in the communication domain. Indeed, CL\/P was associated with significantly lower scores in the communication (coefficient: \u20133.31, 95% CI: \u20135.09 to \u20131.14), problem\u2010solving (coefficient: \u20133.13, 95% CI: \u20135.07 to \u20131.18), and personal\u2010social domains (coefficient: \u20131.99, 95% CI: \u20133.87 to \u20130.11). Trajectories of ASQ\u20103 scores suggest neurodevelopmental delays in children with CL\/P.<\/jats:p>","DOI":"10.1111\/eos.12857","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T13:13:51Z","timestamp":1644930831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Neurodevelopmental trajectories in children with cleft lip and palate: A longitudinal study based on the Japan Environment and Children's Study"],"prefix":"10.1111","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0116-3584","authenticated-orcid":false,"given":"Shinobu","family":"Tsuchiya","sequence":"first","affiliation":[{"name":"Department of Orthodontics and Speech Therapy for Craniofacial Anomalies Tohoku University Hospital  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7000-4547","authenticated-orcid":false,"given":"Masahiro","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Nursing Tohoku Fukushi University  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1134-0898","authenticated-orcid":false,"given":"Haruki","family":"Momma","sequence":"additional","affiliation":[{"name":"Department of Medicine and Science in Sports and Exercise Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8405-9872","authenticated-orcid":false,"given":"Jun","family":"Aida","sequence":"additional","affiliation":[{"name":"Department of Oral Health Promotion Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3038-7202","authenticated-orcid":false,"given":"Ryoichi","family":"Nagatomi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Science in Sports and Exercise Tohoku University Graduate School of Medicine  Sendai Japan"},{"name":"Division of Biomedical Engineering for Health &amp; Welfare Tohoku University Graduate School of Biomedical Engineering  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2521-039X","authenticated-orcid":false,"given":"Nobuo","family":"Yaegashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Arima","sequence":"additional","affiliation":[{"name":"Department of Informative Genetics Environment and Genome Research Centre Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0017-357X","authenticated-orcid":false,"given":"Kaoru","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Speech Therapy for Craniofacial Anomalies Tohoku University Hospital  Sendai Japan"},{"name":"Division of Craniofacial Anomalies Tohoku University Graduate School of Dentistry  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Japan Environment and Children's Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"International Clearinghouse for Birth Defects Surveillance and Research. 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