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KLF4 expression levels were examined in a multicenter cohort of 128 oral squamous cell carcinoma (OSCC) specimens from the tongue (OTSCC) using immunohistochemistry. In two external <jats:italic>KLF4<\/jats:italic> mRNA datasets (The Cancer Genome Atlas\/The Genotype\u2010Tissue Expression Portal), lower <jats:italic>KLF4<\/jats:italic> mRNA expression was found in OSCC and head and neck squamous cell carcinomas (HNSCC) than in control oral epithelium. These data indicate that down\u2010regulation of <jats:italic>KLF4<\/jats:italic> mRNA is linked to OSCC\/HNSCC progression. Using Cox\u2010multivariate analysis, a significantly favorable 5\u2010year disease\u2010specific survival rate was observed for a subgroup of patients with a combination of high levels of KLF4 expression and inflammation. OSCC cell lines exposed to IFN\u2010\u03b3 showed a significant upregulation of nuclear KLF4 expression, indicating a link between inflammation and KLF4 expression in OSCC. Overall, the current data suggest a functional link between KLF4 and inflammation. The combination of high KLF4 nuclear expression and marked\/moderate stromal inflammation might be useful as a favorable prognostic marker for a subgroup of OTSCC patients.<\/jats:p>","DOI":"10.1111\/eos.12866","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T15:39:26Z","timestamp":1648827566000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The prognostic role of combining Kr\u00fcppel\u2010like factor 4 score and grade of inflammation in a Norwegian cohort of oral tongue squamous cell carcinomas"],"prefix":"10.1111","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1687-3247","authenticated-orcid":false,"given":"Tine M.","family":"S\u00f8land","sequence":"first","affiliation":[{"name":"Institute of Oral Biology Faculty of Dentistry University of Oslo  Oslo Norway"},{"name":"Department of Pathology Rikshospitalet Oslo University Hospital  Oslo 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