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One hundred and forty\u2010three individuals were assessed. The amount of external apical root resorption of upper central incisors (EARR<jats:sub>inc<\/jats:sub>) and lower first molars (EARR<jats:sub>mol<\/jats:sub>) were evaluated in radiographs. Seven SNPs were genotyped across four genes including the vitamin D receptor [<jats:italic>VDR<\/jats:italic>], group\u2010specific component [<jats:italic>GC<\/jats:italic>], cytochrome P450 family 27 subfamily B member 1 [<jats:italic>CYP27B1<\/jats:italic>], and cytochrome P450 family 24 subfamily A member 1 [<jats:italic>CYP24A1<\/jats:italic>]. Linear regressions were implemented to determine allele\u2010effects on external apical root resorption. Individuals carrying the AA genotype in <jats:italic>VDR<\/jats:italic> rs2228570 had a 21% higher EARR<jats:sub>mol<\/jats:sub> than those having AG and GG genotypes (95% CI: 1.03,1.40). EARR<jats:sub>mol<\/jats:sub> in heterozygous rs2228570, was 12% lower than for homozygotes (95%CI: 0.78,0.99). Participants with the CCG haplotype (rs1544410\u2010rs7975232\u2010rs731236) in <jats:italic>VDR<\/jats:italic> had an EARR<jats:sub>mol<\/jats:sub> 16% lower than those who did not carry this haplotype. Regarding <jats:italic>CYP27B1<\/jats:italic> rs4646536, EARR<jats:sub>inc<\/jats:sub> in participants who had at least one G allele was 42% lower than for homozygotes AA (95%CI: 0.37,0.93). Although these results did not remain significant after multiple testing adjustment, potential associations may still be suggested. Further replication studies are needed to confirm or refute these findings.<\/jats:p>","DOI":"10.1111\/eos.12916","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T02:53:30Z","timestamp":1674442410000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association between genetic variants in key vitamin\u2010D\u2010pathway genes and external apical root resorption linked to orthodontic treatment"],"prefix":"10.1111","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7029-0347","authenticated-orcid":false,"given":"G.","family":"Mara\u00f1\u00f3n\u2010V\u00e1squez","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry and Orthodontics School of Dentistry Federal University of Rio de Janeiro, Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5351-2526","authenticated-orcid":false,"given":"EC.","family":"K\u00fcchler","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University Medical Centre of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3800-0415","authenticated-orcid":false,"given":"S.","family":"Hermann","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University Medical Centre of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8207-5257","authenticated-orcid":false,"given":"E","family":"Paddenberg","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University Medical Centre of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6010-9831","authenticated-orcid":false,"given":"A.","family":"Schr\u00f6der","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University Medical Centre of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5649-7234","authenticated-orcid":false,"given":"F.","family":"Baratto\u2010Filho","sequence":"additional","affiliation":[{"name":"Department of Dentistry School of Dentistry Univille \u2010 University of the Joinville Region  Joinville Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0887-9385","authenticated-orcid":false,"given":"C.","family":"Flores\u2010Mir","sequence":"additional","affiliation":[{"name":"Division of Orthodontics School of Dentistry Faculty of Medicine and Dentistry University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1137-5361","authenticated-orcid":false,"given":"P.","family":"Proff","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University Medical Centre of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9473-8724","authenticated-orcid":false,"given":"C.","family":"Kirschneck","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University Medical Centre of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,22]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"175","article-title":"Orthodontically induced inflammatory root resorption. 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