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Cortactin amplification and overexpression, a common molecular alteration in oral squamous cell carcinomas, have been linked to invasion and metastasis of tumor cells. However, the intra\u2010tumor expression pattern and prognostic significance of cortactin in human papillomavirus (HPV) negative OTSCC is not fully investigated. Immunohistochemical analysis using tissue microarray consisting of formalin\u2010fixed and paraffin\u2010embedded HPV negative OTSCC (<jats:italic>n<\/jats:italic>\u00a0=\u00a0123) specimens showed overexpression of cortactin at tissue cores from invading fronts as compared to the corresponding center cores. High overall cortactin expression was found to be associated with advanced (larger) tumor size and the occurrence of distance metastasis. Kaplan\u2010Meier survival analysis showed that patients with high overall cortactin expression were associated with reduced 5\u2010year survival. Multivariate Cox regression analysis identified high cortactin expression to be an independent prognostic factor in OTSCC. Additionally, siRNA\u2010mediated silencing of cortactin was found to suppress the proliferative and invasive abilities of OTSCC cells in an organotypic co\u2010culture model. Overexpression of cortactin is a promising prognostic marker in HPV\u2010negative OTSCC.<\/jats:p>","DOI":"10.1111\/eos.12925","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T13:33:19Z","timestamp":1676467999000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cortactin expression in a Norwegian cohort of human papilloma virus negative oral squamous cell carcinomas of the mobile tongue"],"prefix":"10.1111","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1507-4662","authenticated-orcid":false,"given":"B.","family":"Seng\u00fcven Tok\u00f6zl\u00fc","sequence":"first","affiliation":[{"name":"Department of Oral Biology Faculty of Dentistry University of Oslo  Oslo Norway"},{"name":"Department of Oral Pathology Faculty of Dentistry Gazi University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0061-825X","authenticated-orcid":false,"given":"D.","family":"Sapkota","sequence":"additional","affiliation":[{"name":"Department of Oral Biology Faculty of Dentistry University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4852-8608","authenticated-orcid":false,"given":"E. 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