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The study was a randomised, controlled double\u2010blind parallel clinical trial (<jats:italic>n<\/jats:italic>\u00a0=\u00a024\/group) measuring salivary fluoride five times during a 3\u2010week trial phase involving 2\u00d7\/day use of 5000 or 1450\u00a0ppm fluoride toothpaste, and five times during an ensuing 2\u2010week wash\u2010out phase where all participants used 1450\u00a0ppm toothpaste. Salivary fluoride was measured using a fluoride electrode and data were analysed using multilevel mixed\u2010effects linear regression. Baseline salivary fluoride geometric means were 0.014 and 0.016\u00a0ppm for the 1450 and 5000\u00a0ppm groups, while the values at the end of the trial phase were 0.023 and 0.044\u00a0ppm, respectively. During the trial phase, except at baseline, differences between groups were statistically significant. The salivary fluoride levels for the 5000\u00a0ppm group remained statistically significantly higher than for the 1450\u00a0ppm group only at the first measurement in the wash\u2010out phase (\u224830\u00a0h after the last 5000\u00a0ppm brushing), indicating that higher salivary fluoride levels resulting from use of 5000\u00a0ppm are sustained only as long as the brushing habit continues.<\/jats:p>","DOI":"10.1111\/eos.12934","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T01:49:27Z","timestamp":1682992167000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Salivary fluoride levels after daily brushing with 5000\u00a0ppm fluoride toothpaste: A randomised, controlled clinical trial"],"prefix":"10.1111","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4155-5884","authenticated-orcid":false,"given":"L.","family":"Staun 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