{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T11:50:02Z","timestamp":1774525802871,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:00:00Z","timestamp":1692316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Radiographic findings from long\u2010term studies of periodontitis treatment have rarely been reported. Although bone destruction is a prominent feature of periodontitis, the long\u2010term effect on alveolar bone levels of different treatment strategies, with or without adjunctive metronidazole (MTZ), has not been reported. We investigated the 5\u2010year radiographic outcome of therapy in patient groups treated with conventional scaling and root planing (SRP) or same\u2010day full\u2010mouth disinfection (FDIS), with or without adjunctive MTZ. Following a 3\u2010month oral hygiene phase, 184 periodontitis patients were randomly allocated to one of four treatment regimens: (i) FDIS+MTZ; (ii) FDIS+placebo; (iii) SRP+MTZ; or (iv) SRP+placebo. Following active treatment, patients received biannual maintenance. In total, 161 patients (87.5%) completed the 5\u2010year follow\u2010up examination, at which the radiographic bone level (RBL), clinical attachment level, probing pocket depth, presence of plaque, and bleeding were recorded again. At the 5\u2010year follow up examination, minor radiological bone loss was observed in the intervention groups FDIS+placebo, SRP+MTZ, and SRP+placebo; by contrast, the FDIS+MTZ group did not show any change in RBL. Full\u2010mouth disinfection did not generally perform better than conventional SRP performed over a period of 2 to 4\u00a0weeks.<\/jats:p>","DOI":"10.1111\/eos.12949","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T23:41:09Z","timestamp":1692661269000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Five\u2010year radiological findings from a randomized controlled trial of four periodontitis treatment strategies"],"prefix":"10.1111","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4377-2049","authenticated-orcid":false,"given":"Jon Olav","family":"Kubber\u00f8d","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Institute of Clinical Odontology University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8335-7053","authenticated-orcid":false,"given":"Gerald Ruiner","family":"Torgersen","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Radiology Institute of Clinical Odontology Faculty of Dentistry University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0341-8958","authenticated-orcid":false,"given":"Per","family":"Gjermo","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Institute of Clinical Odontology University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2195-8053","authenticated-orcid":false,"given":"Vibeke","family":"Baelum","sequence":"additional","affiliation":[{"name":"Department of Odontology and Oral Health Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6516-6621","authenticated-orcid":false,"given":"Hans R.","family":"Preus","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Institute of Clinical Odontology University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12121"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010015\u20100123\u20106"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-775720140453"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.140620"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160332"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12793"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120400"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1965.36.3.177"},{"key":"e_1_2_8_10_1","first-page":"273","article-title":"Response of chronic gingivitis to hygiene therapy and experimental gingivitis. Clinical, microbiological and metabonomic changes","volume":"28","author":"Klukowska M","year":"2015","journal-title":"Am J Dent"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1979.tb00229.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1982.tb02048.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01383.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.157001"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0006"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12903\u2010015\u20100037\u20103"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18\u20100157"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6979.2004.00433.x"},{"key":"e_1_2_8_19_1","first-page":"456","volume-title":"Practical statistics for medical research","author":"Altman DG","year":"1991"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060264"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00822.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0721"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1982.tb02058.x"},{"key":"e_1_2_8_25_1","unstructured":"RasbandWS.ImageJ.U.S. National Institutes of Health. Bethesda Maryland USA.1997\u20102014.http:\/\/imagej.nih.gov\/ij\/"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010015\u20100092\u20109"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.86.2.420"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-37131-8_2"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13207"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2009.00339.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v7.26941"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1977.tb02271.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1986.tb01449.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.4.247"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1992.tb00448.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00485.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4809695"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.3.275"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00605.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.290410.x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00905.x"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12089"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01763.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280106.x"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345950740080501"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2008.00292.x"},{"key":"e_1_2_8_48_1","first-page":"393","article-title":"Metronidazole and the immune system","volume":"66","author":"Shakir L","year":"2011","journal-title":"Pharmazie"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1986.tb02802.x"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.190105"}],"container-title":["European Journal of Oral Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eos.12949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T03:15:48Z","timestamp":1698981348000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eos.12949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,18]]},"references-count":49,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/eos.12949"],"URL":"https:\/\/doi.org\/10.1111\/eos.12949","archive":["Portico"],"relation":{},"ISSN":["0909-8836","1600-0722"],"issn-type":[{"value":"0909-8836","type":"print"},{"value":"1600-0722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,18]]},"assertion":[{"value":"2023-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12949"}}